Defining epithelial cell contributions to inflammatory bowel disease (IBD) is essential for the development of much needed therapies for barrier repair. Children with very early onset (VEO)-IBD have more extensive, severe, and refractory disease than older children and adults with IBD and, in some cases, have defective barrier function. We therefore evaluated functional and transcriptomic differences between pediatric IBD (VEO and older onset) and non-IBD epithelium using 3-dimensional, biopsy-derived organoids.
Colonoids From Patients With Pediatric Inflammatory Bowel Disease Exhibit Decreased Growth Associated With Inflammation Severity and Durable Upregulation of Antigen Presentation Genes / Kelsen, Judith R; Dawany, Noor; Conrad, Maire A; Karakasheva, Tatiana A; Maurer, Kelly; Wei, Jane M; Uman, Selen; Dent, Maiah H; Behera, Rithika; Bryant, Laura M; Ma, Xianghui; Moreira, Leticia; Chatterji, Priya; Shraim, Rawan; Merz, Audrey; Mizuno, Rei; Simon, Lauren A; Muir, Amanda B; Giraudo, Claudio; Behrens, Edward M; Whelan, Kelly A; Devoto, Marcella; Russo, Pierre A; Andres, Sarah F; Sullivan, Kathleen E; Hamilton, Kathryn E. - In: INFLAMMATORY BOWEL DISEASES. - ISSN 1078-0998. - 27:2(2021), pp. 256-267-267. [10.1093/ibd/izaa145]
Colonoids From Patients With Pediatric Inflammatory Bowel Disease Exhibit Decreased Growth Associated With Inflammation Severity and Durable Upregulation of Antigen Presentation Genes
Devoto, Marcella;
2021
Abstract
Defining epithelial cell contributions to inflammatory bowel disease (IBD) is essential for the development of much needed therapies for barrier repair. Children with very early onset (VEO)-IBD have more extensive, severe, and refractory disease than older children and adults with IBD and, in some cases, have defective barrier function. We therefore evaluated functional and transcriptomic differences between pediatric IBD (VEO and older onset) and non-IBD epithelium using 3-dimensional, biopsy-derived organoids.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
