In this issue of Blood, van Halteren and colleagues demonstrate that not only antigen-specific CD8 + CTLs, but also antigen-specific CD8 + T regs can emerge during pregnancy and persist over time when mother and offspring differ for minor histocompatibility antigens.1 The relative ratio between these 2 populations, either promoting aggression against allogeneic tissues or tumor cells or tolerance toward alloantigens, is of potential great relevance in the context of HSCT.
Tolerance: Pregnancy matters / Locatelli, F.. - In: BLOOD. - ISSN 0006-4971. - 114:11(2009), pp. 2208-2209. [10.1182/blood-2009-06-228528]
Tolerance: Pregnancy matters
Locatelli F.
2009
Abstract
In this issue of Blood, van Halteren and colleagues demonstrate that not only antigen-specific CD8 + CTLs, but also antigen-specific CD8 + T regs can emerge during pregnancy and persist over time when mother and offspring differ for minor histocompatibility antigens.1 The relative ratio between these 2 populations, either promoting aggression against allogeneic tissues or tumor cells or tolerance toward alloantigens, is of potential great relevance in the context of HSCT.File allegati a questo prodotto
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