Kidney transplantation is the golden treatment for end‐stage renal disease. Static cold  storage is currently considered the standard method of preservation, but dynamic techniques, such  as machine perfusion (MP), have been shown to improve graft function, especially in kidneys donated by extended criteria donors and donation after circulatory death. With poor organ quality  being a major reason for kidneys not being transplanted, an accurate, objective and reliable quality  assessment during preservation could add value and support to clinicians’ decisions. MPs are  emerging technologies with the potential to assess kidney graft viability and quality, both in the  hypothermic and normothermic scenarios. The aim of this review is to summarize current tools for  graft viability assessment using MP prior to implantation in relation to the ischemic damage. 

Assessing kidney graft viability and its cells metabolism during machine perfusion / Bellini, MARIA IRENE; Tortorici, Francesco; Amabile, MARIA IDA; D'Andrea, Vito. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - (2021). [doi.org/ 10.3390/ijms22031121]

Assessing kidney graft viability and its cells metabolism during machine perfusion

Bellini Maria Irene;Amabile Maria Ida;D'Andrea Vito
2021

Abstract

 Kidney transplantation is the golden treatment for end‐stage renal disease. Static cold  storage is currently considered the standard method of preservation, but dynamic techniques, such  as machine perfusion (MP), have been shown to improve graft function, especially in kidneys donated by extended criteria donors and donation after circulatory death. With poor organ quality  being a major reason for kidneys not being transplanted, an accurate, objective and reliable quality  assessment during preservation could add value and support to clinicians’ decisions. MPs are  emerging technologies with the potential to assess kidney graft viability and quality, both in the  hypothermic and normothermic scenarios. The aim of this review is to summarize current tools for  graft viability assessment using MP prior to implantation in relation to the ischemic damage. 
2021
 ischemic reperfusion injury; kidney transplantation; organ preservation 
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Assessing kidney graft viability and its cells metabolism during machine perfusion / Bellini, MARIA IRENE; Tortorici, Francesco; Amabile, MARIA IDA; D'Andrea, Vito. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - (2021). [doi.org/ 10.3390/ijms22031121]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1479626
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