Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005). Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies.

Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms / Pascarelli, M. T.; Del Percio, C.; De Pandis, M. F.; Ferri, R.; Lizio, R.; Noce, G.; Lopez, S.; Rizzo, M.; Soricelli, A.; Nobili, F.; Arnaldi, D.; Fama, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Salvetti, M.; Cipollini, V.; Franciotti, R.; Onofri, M.; Fuhr, P.; Gschwandtner, U.; Ransmayr, G.; Aarsland, D.; Parnetti, L.; Farotti, L.; Marizzoni, M.; D'Antonio, F.; De Lena, C.; Guntekin, B.; Hanoglu, L.; Yener, G.; Emek-Savas, D. D.; Ivano Triggiani, A.; Paul Taylor, J.; Mckeith, I.; Stocchi, F.; Vacca, L.; Hampel, H.; Frisoni, G. B.; Bonanni, L.; Babiloni, C.. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 131:11(2020), pp. 2716-2731. [10.1016/j.clinph.2020.09.004]

Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms

Pascarelli M. T.;Del Percio C.;Ferri R.;Lizio R.;Noce G.;Lopez S.;Arnaldi D.;Orzi F.;Buttinelli C.;Giubilei F.;Salvetti M.;Cipollini V.;D'Antonio F.;De Lena C.;Stocchi F.;Babiloni C.
2020

Abstract

Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005). Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies.
Exact low-resolution brain electromagnetic source tomography (eLORETA); Mild cognitive impairment (MCI); Prodromal and overt dementia with Lewy bodies (DLB); Rapid eye movement sleep behavior disorders (RBD); Resting state electroencephalographic (EEG) rhythms; Visual hallucinations
01 Pubblicazione su rivista::01a Articolo in rivista
Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms / Pascarelli, M. T.; Del Percio, C.; De Pandis, M. F.; Ferri, R.; Lizio, R.; Noce, G.; Lopez, S.; Rizzo, M.; Soricelli, A.; Nobili, F.; Arnaldi, D.; Fama, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Salvetti, M.; Cipollini, V.; Franciotti, R.; Onofri, M.; Fuhr, P.; Gschwandtner, U.; Ransmayr, G.; Aarsland, D.; Parnetti, L.; Farotti, L.; Marizzoni, M.; D'Antonio, F.; De Lena, C.; Guntekin, B.; Hanoglu, L.; Yener, G.; Emek-Savas, D. D.; Ivano Triggiani, A.; Paul Taylor, J.; Mckeith, I.; Stocchi, F.; Vacca, L.; Hampel, H.; Frisoni, G. B.; Bonanni, L.; Babiloni, C.. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 131:11(2020), pp. 2716-2731. [10.1016/j.clinph.2020.09.004]
File allegati a questo prodotto
File Dimensione Formato  
Pascarelli_Abnormalities_2020.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 2.32 MB
Formato Adobe PDF
2.32 MB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1477827
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact