Urolithiasis is the process of stone formation in the urinary tract. Its etiology is only partly known, and efficient therapeutic approaches are currently lacking. Metabolomics is increasingly used in biomarkers discovery for its ability to identify mediators of relevant (patho)physiological processes. Amino acids may be involved in kidney stone formation. The aim of the present study was to investigate the presence of an amino acid signature in stone former urine through a targeted metabolomic approach.

A Specific Urinary Amino Acid Profile Characterizes People with Kidney Stones / Primiano, Aniello; Persichilli, Silvia; Ferraro, Pietro Manuel; Calvani, Riccardo; Biancolillo, Alessandra; Marini, Federico; Picca, Anna; Marzetti, Emanuele; Urbani, Andrea; Gervasoni, Jacopo. - In: DISEASE MARKERS. - ISSN 0278-0240. - 2020:(2020), pp. 1-7. [10.1155/2020/8848225]

A Specific Urinary Amino Acid Profile Characterizes People with Kidney Stones

Marini, Federico;
2020

Abstract

Urolithiasis is the process of stone formation in the urinary tract. Its etiology is only partly known, and efficient therapeutic approaches are currently lacking. Metabolomics is increasingly used in biomarkers discovery for its ability to identify mediators of relevant (patho)physiological processes. Amino acids may be involved in kidney stone formation. The aim of the present study was to investigate the presence of an amino acid signature in stone former urine through a targeted metabolomic approach.
2020
liquid chromatography-mass spectrometry; case-control study; partial least squares- discriminant analysis (PLS-DA); metabolomics
01 Pubblicazione su rivista::01a Articolo in rivista
A Specific Urinary Amino Acid Profile Characterizes People with Kidney Stones / Primiano, Aniello; Persichilli, Silvia; Ferraro, Pietro Manuel; Calvani, Riccardo; Biancolillo, Alessandra; Marini, Federico; Picca, Anna; Marzetti, Emanuele; Urbani, Andrea; Gervasoni, Jacopo. - In: DISEASE MARKERS. - ISSN 0278-0240. - 2020:(2020), pp. 1-7. [10.1155/2020/8848225]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1477024
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