During development, innate lymphocytes acquire defined sets of primed enhancers facilitating the rapid immune response. In this issue of Immunity, Sciumè et al. delineate the epigenetic changes occurring during acute NK cell activation, revealing the formation of de novo enhancers and repurposing of both lineage-determining and signal-regulated transcription factors.
Rapid enhancer remodeling and transcription factor repurposing enable high magnitude gene induction upon acute activation of NK cells / Sciume, Giuseppe.; Mikami, Y.; Jankovic, D.; Nagashima, H.; Villarino, A. V.; Morrison, T.; Yao, C.; Signorella, S.; Sun, H. -W.; Brooks, S. R.; Fang, D.; Sartorelli, V.; Nakayamada, S.; Hirahara, K.; Zitti, B.; Davis, F. P.; Kanno, Y.; O'Shea, J. J.; Shih, H. -Y.. - In: IMMUNITY. - ISSN 1074-7613. - 53:4(2020), pp. 745-758.e4. [10.1016/j.immuni.2020.09.008]
Rapid enhancer remodeling and transcription factor repurposing enable high magnitude gene induction upon acute activation of NK cells
Sciume Giuseppe.Primo
Investigation
;
2020
Abstract
During development, innate lymphocytes acquire defined sets of primed enhancers facilitating the rapid immune response. In this issue of Immunity, Sciumè et al. delineate the epigenetic changes occurring during acute NK cell activation, revealing the formation of de novo enhancers and repurposing of both lineage-determining and signal-regulated transcription factors.| File | Dimensione | Formato | |
|---|---|---|---|
|
Sciumè_Rapid-enhancer_2020.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
7.23 MB
Formato
Adobe PDF
|
7.23 MB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
