Neuropathic pain is caused by a lesion or disease of the somatosensory system, including peripheral fibres (Aβ, AÎ and C fibres) and central neurons, and affects 7-10% of the general population. Multiple causes of neuropathic pain have been described and its incidence is likely to increase owing to the ageing global population, increased incidence of diabetes mellitus and improved survival from cancer after chemotherapy. Indeed, imbalances between excitatory and inhibitory somatosensory signalling, alterations in ion channels and variability in the way that pain messages are modulated in the central nervous system all have been implicated in neuropathic pain. The burden of chronic neuropathic pain seems to be related to the complexity of neuropathic symptoms, poor outcomes and difficult treatment decisions. Importantly, quality of life is impaired in patients with neuropathic pain owing to increased drug prescriptions and visits to health care providers, as well as the morbidity from the pain itself and the inciting disease. Despite challenges, progress in the understanding of the pathophysiology of neuropathic pain is spurring the development of new diagnostic procedures and personalized interventions, which emphasize the need for a multidisciplinary approach to the management of neuropathic pain.

Neuropathic pain / Colloca, L.; Ludman, T.; Bouhassira, D.; Baron, R.; Dickenson, A. H.; Yarnitsky, D.; Freeman, R.; Truini, A.; Attal, N.; Finnerup, N. B.; Eccleston, C.; Kalso, E.; Bennett, D. L.; Dworkin, R. H.; Raja, S. N.. - In: NATURE REVIEWS. DISEASE PRIMERS. - ISSN 2056-676X. - 3:1(2017), p. 17002. [10.1038/nrdp.2017.2]

Neuropathic pain

Truini A.;
2017

Abstract

Neuropathic pain is caused by a lesion or disease of the somatosensory system, including peripheral fibres (Aβ, AÎ and C fibres) and central neurons, and affects 7-10% of the general population. Multiple causes of neuropathic pain have been described and its incidence is likely to increase owing to the ageing global population, increased incidence of diabetes mellitus and improved survival from cancer after chemotherapy. Indeed, imbalances between excitatory and inhibitory somatosensory signalling, alterations in ion channels and variability in the way that pain messages are modulated in the central nervous system all have been implicated in neuropathic pain. The burden of chronic neuropathic pain seems to be related to the complexity of neuropathic symptoms, poor outcomes and difficult treatment decisions. Importantly, quality of life is impaired in patients with neuropathic pain owing to increased drug prescriptions and visits to health care providers, as well as the morbidity from the pain itself and the inciting disease. Despite challenges, progress in the understanding of the pathophysiology of neuropathic pain is spurring the development of new diagnostic procedures and personalized interventions, which emphasize the need for a multidisciplinary approach to the management of neuropathic pain.
2017
Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; Humans; Lidocaine; Narcotics; Neoplasms; Neuralgia; Nociceptive Pain; Pain Management; Pregabalin; Quality of Life; Tramadol; Transcutaneous Electric Nerve Stimulation; Voltage-Gated Sodium Channel Blockers; gamma-Aminobutyric Acid
01 Pubblicazione su rivista::01a Articolo in rivista
Neuropathic pain / Colloca, L.; Ludman, T.; Bouhassira, D.; Baron, R.; Dickenson, A. H.; Yarnitsky, D.; Freeman, R.; Truini, A.; Attal, N.; Finnerup, N. B.; Eccleston, C.; Kalso, E.; Bennett, D. L.; Dworkin, R. H.; Raja, S. N.. - In: NATURE REVIEWS. DISEASE PRIMERS. - ISSN 2056-676X. - 3:1(2017), p. 17002. [10.1038/nrdp.2017.2]
File allegati a questo prodotto
File Dimensione Formato  
Colloca_Neuropathic pain_2017.pdf

solo gestori archivio

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.46 MB
Formato Adobe PDF
2.46 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1475542
Citazioni
  • ???jsp.display-item.citation.pmc??? 398
  • Scopus 1406
  • ???jsp.display-item.citation.isi??? 1288
social impact