The inhibitory mechanism named backward inhibition (BI) counteracts interference of previous tasks supporting task switching. For instance, if task set A is inhibited when switching to task B, then it should take longer to immediately return to task set A (as occurring in an ABA sequence), as compared to a task set that has not been just inhibited (as occurring in a CBA sequence), because extra time will be needed to overcome the inhibition of task set A. The evidenced prefrontal and cerebellar role in inhibitory control suggests their involvement even in BI. Here, for the first time, we modulated the excitability of multiple brain sites (right presupplementary motor area (pre-SMA), left and right cerebellar hemispheres) through continuous theta burst stimulation (cTBS) in a valuable sham-controlled order-balanced within-subject experimental design in healthy individuals performing two domain-selective (verbal and spatial) task-switching paradigms. Verbal BI was abolished by prefrontal or cerebellar stimulations through opposite alterations of the basal pattern: cTBS on pre-SMA increased CBA reaction times, disclosing the current prefrontal inhibition of any interfering old task. Conversely, cerebellar cTBS decreased ABA reaction times, disclosing the current cerebellar recognition of sequences in which it is necessary to overcome previously inhibited events.

Out with the old and in with the new: the contribution of prefrontal and cerebellar areas to backward inhibition / Picazio, S.; Foti, F.; Oliveri, M.; Koch, G.; Petrosini, L.; Ferlazzo, F.; Sdoia, S.. - In: THE CEREBELLUM. - ISSN 1473-4222. - 19:3(2020), pp. 426-436. [10.1007/s12311-020-01115-9]

Out with the old and in with the new: the contribution of prefrontal and cerebellar areas to backward inhibition

Picazio S.
;
Petrosini L.;Ferlazzo F.;Sdoia S.
2020

Abstract

The inhibitory mechanism named backward inhibition (BI) counteracts interference of previous tasks supporting task switching. For instance, if task set A is inhibited when switching to task B, then it should take longer to immediately return to task set A (as occurring in an ABA sequence), as compared to a task set that has not been just inhibited (as occurring in a CBA sequence), because extra time will be needed to overcome the inhibition of task set A. The evidenced prefrontal and cerebellar role in inhibitory control suggests their involvement even in BI. Here, for the first time, we modulated the excitability of multiple brain sites (right presupplementary motor area (pre-SMA), left and right cerebellar hemispheres) through continuous theta burst stimulation (cTBS) in a valuable sham-controlled order-balanced within-subject experimental design in healthy individuals performing two domain-selective (verbal and spatial) task-switching paradigms. Verbal BI was abolished by prefrontal or cerebellar stimulations through opposite alterations of the basal pattern: cTBS on pre-SMA increased CBA reaction times, disclosing the current prefrontal inhibition of any interfering old task. Conversely, cerebellar cTBS decreased ABA reaction times, disclosing the current cerebellar recognition of sequences in which it is necessary to overcome previously inhibited events.
2020
executive functions; inhibitory control; task-switching; theta burst stimulation; transcranial magnetic stimulation
01 Pubblicazione su rivista::01a Articolo in rivista
Out with the old and in with the new: the contribution of prefrontal and cerebellar areas to backward inhibition / Picazio, S.; Foti, F.; Oliveri, M.; Koch, G.; Petrosini, L.; Ferlazzo, F.; Sdoia, S.. - In: THE CEREBELLUM. - ISSN 1473-4222. - 19:3(2020), pp. 426-436. [10.1007/s12311-020-01115-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1475403
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