Background and purpose: In relapsing-remitting multiple sclerosis patients (RRMS) disability progressively accumulates over time. To compare the cumulative probability of 6-month confirmed disability-worsening events using a fixed baseline or a roving Expanded Disability Status Scale (EDSS) reference, in a real-world setting. Methods: A cohort of 7964 RRMS patients followed for 2 or more years, with EDSS scores recorded every 6 months, was selected from the Italian Multiple Sclerosis Register. The overall probability of confirmed disability-worsening events and of confirmed disability-worsening events unrelated to relapse was evaluated using as reference a fixed baseline EDSS score or a roving EDSS score in which the increase had to be separated from the last EDSS assessment by at least 6 or 12 months. Results: Using a fixed baseline EDSS reference, the cumulative probability of 6-year overall confirmed disability-worsening events was 33.2%, and that of events unrelated to relapse was 10.9% (33% of overall confirmed disability-worsening events). Using a roving EDSS, the proportions were respectively 35.2% and 21.3% (61% of overall confirmed disability-worsening events). Conclusions: In a real-world setting, roving EDSS reference scores appear to be more sensitive for detecting confirmed disability-worsening events unrelated to relapse in RRMS patients.
Detection of disability worsening in relapsing-remitting multiple sclerosis patients: a real-world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register / Lepore, V.; Bosetti, C.; Santucci, C.; Iaffaldano, P.; Trojano, M.; Mosconi, P.; Totaro, R.; Coniglio, M. G.; Bossio, R. B.; Valentino, P.; Gatto, M.; Paolicelli, D.; Ardito, B.; Barcella, V.; Capone, L.; Nicolao, P.; Lugaresi, A.; Rini, A.; Bianchi, M.; Plasmati, I.; Cocco, E.; Docimo, R.; De Luca, G.; Mondino, F.; Di Sapio, A.; Clerici, R.; Mascoli, N.; Ferro, M. T.; Chisari, C. G.; Maimone, D.; Strumia, S.; Pugliatti, M.; Cargnelutti, D.; Caniatti, L. M.; Avolio, C.; Crociani, P.; Amato, M. P.; Massacesi, L.; Malagu, S.; Ribizzi, G.; Inglese, M.; Venturi, S.; Gazzola, P.; Pizio, N. R.; Brichetto, G.; Plewnia, K.; Bellantonio, P.; Balgera, R.; De Robertis, F.; Fermi, S.; Fausto, F.; Mazzoni, M.; Meucci, G.; Cartechini, E.; Cavaletti, G.; Buccafusca, M.; Bramanti, P.; Romeo, M.; Rovaris, M.; Ronzoni, M.; Confalonieri, P.; Chiveri, L.; Bertora, P.; Tonietti, S.; De Riz, M.; Protti, A.; Sola, P.; Maremmani, C.; Lus, G.; Gallo, A.; Maniscalco, G. T.; Morra, V. B.; Cacchio, G.; Iodice, R.; Ragno, M.; Sinisi, L.; Cantello, R.; Piras, M. L.; Salemi, G.; Cottone, S.; Grimaldi, L. M. E.; Corea, F.; Santangelo, G.; Immovili, P.; Gallo, P.; D'Andrea, F.; Frittelli, C.; Pasquali, L.; Falcini, M.; Granella, F.; Pesci, I.; Ancona, A. L.; Bergamaschi, R.; Giordano, A.; Di Napoli, M.; Romano, S.; Pozzilli, C.; Mirabella, M.; Conte, A.; Galgani, S.; Peresson, M.; Grasso, M. G.; Ferraro, E.; Capone, F.; Marfia, G. A.; de Pascalis, D.; Piantadosi, C.; Valeriani, M.; Busillo, V.; Barone, P.; De Stefano, N.; Ulivelli, M.; Santuccio, G.; Parodi, S.; Bucello, S.; Traccis, S.; Zarbo, R.; Tassinari, T.; Bandini, F.; Cavalla, P.; Clerico, M.; De Rosa, G.; Bertolotto, A.; Imperiale, D.; Sarchielli, P.; Celani, M. G.; Vianello, M.; Marini, B.; Fortunato, M.; Zaffaroni, M.; Nasuelli, D.; Banfi, P.; Brioschi, A. M.; Solaro, C.; Quatrale, R.; Rossi, P.; Gajofatto, A.; Trojano, M.; Battaglia, M. A.; Capobianco, M.; Pugliatti, M.; Ulivelli, M.; Mosconi, P.; Patti, F.; Amato, M. P.; Bergamaschi, R.; Comi, G.. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - (2021). [10.1111/ene.14589]
Detection of disability worsening in relapsing-remitting multiple sclerosis patients: a real-world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register
Rovaris M.;Romano S.;Pozzilli C.;Conte A.;
2021
Abstract
Background and purpose: In relapsing-remitting multiple sclerosis patients (RRMS) disability progressively accumulates over time. To compare the cumulative probability of 6-month confirmed disability-worsening events using a fixed baseline or a roving Expanded Disability Status Scale (EDSS) reference, in a real-world setting. Methods: A cohort of 7964 RRMS patients followed for 2 or more years, with EDSS scores recorded every 6 months, was selected from the Italian Multiple Sclerosis Register. The overall probability of confirmed disability-worsening events and of confirmed disability-worsening events unrelated to relapse was evaluated using as reference a fixed baseline EDSS score or a roving EDSS score in which the increase had to be separated from the last EDSS assessment by at least 6 or 12 months. Results: Using a fixed baseline EDSS reference, the cumulative probability of 6-year overall confirmed disability-worsening events was 33.2%, and that of events unrelated to relapse was 10.9% (33% of overall confirmed disability-worsening events). Using a roving EDSS, the proportions were respectively 35.2% and 21.3% (61% of overall confirmed disability-worsening events). Conclusions: In a real-world setting, roving EDSS reference scores appear to be more sensitive for detecting confirmed disability-worsening events unrelated to relapse in RRMS patients.| File | Dimensione | Formato | |
|---|---|---|---|
|
Lepore_Detection_2021.pdf
solo gestori archivio
Tipologia:
Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
11.51 MB
Formato
Adobe PDF
|
11.51 MB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
