Initial studies on renal denervation (RDN) for the treatment of non-controlled arterial hypertension (HTN) through radiofrequency ablation of renal arteries demonstrated that RDN is an effective therapeutic strategy to reduce arterial blood pressure (BP). Nonetheless, the first randomized study, SYMPLICITY-HTN-3, failed to demonstrate a clear benefit for RND over the control group. Technologic evolution, with the introduction of new second generation multi-electrode devices, allowed deep energy delivery along the full circumference of the vessel. Two recent randomized studies involving patients assuming (SPYRAL HTN-ON MED) or not (SPYRAL HTN-OFF MED) antihypertensive pharmacologic treatment, demonstrated the efficacy and safety of RDN using second generation systems for radiofrequency ablation. Another recent randomized study demonstrated that RDN with ultrasounds (RADIANCE-HTN SOLO) of the main renal arteries led to a significant BP reduction compared to the control group. These studies have once again raised the interest of the scientific community towards attempting to define the appropriate role of RDN in the treatment of hypertension. Nonetheless, larger and longer clinical trials will be necessary to draw further conclusions.

Renal arteries denervation with second generation systems: a remedy for resistant hypertension? / Versaci, Francesco; Sciarretta, Sebastiano; Scappaticci, Massimiliano; Calcagno, Simone; di Pietro, Riccardo; Sbandi, Francesca; Dei Giudici, Angela; Del Prete, Armando; de Angelis, Stefano; Biondi-Zoccai, Giuseppe. - In: EUROPEAN HEART JOURNAL SUPPLEMENTS. - ISSN 1520-765X. - 22:Suppl L(2020), pp. L160-L165-L165. [10.1093/eurheartj/suaa158]

Renal arteries denervation with second generation systems: a remedy for resistant hypertension?

Sciarretta, Sebastiano;Calcagno, Simone;di Pietro, Riccardo;Biondi-Zoccai, Giuseppe
2020

Abstract

Initial studies on renal denervation (RDN) for the treatment of non-controlled arterial hypertension (HTN) through radiofrequency ablation of renal arteries demonstrated that RDN is an effective therapeutic strategy to reduce arterial blood pressure (BP). Nonetheless, the first randomized study, SYMPLICITY-HTN-3, failed to demonstrate a clear benefit for RND over the control group. Technologic evolution, with the introduction of new second generation multi-electrode devices, allowed deep energy delivery along the full circumference of the vessel. Two recent randomized studies involving patients assuming (SPYRAL HTN-ON MED) or not (SPYRAL HTN-OFF MED) antihypertensive pharmacologic treatment, demonstrated the efficacy and safety of RDN using second generation systems for radiofrequency ablation. Another recent randomized study demonstrated that RDN with ultrasounds (RADIANCE-HTN SOLO) of the main renal arteries led to a significant BP reduction compared to the control group. These studies have once again raised the interest of the scientific community towards attempting to define the appropriate role of RDN in the treatment of hypertension. Nonetheless, larger and longer clinical trials will be necessary to draw further conclusions.
2020
Arterial hypertension; Renal arteries; Sympathetic nervous system
01 Pubblicazione su rivista::01a Articolo in rivista
Renal arteries denervation with second generation systems: a remedy for resistant hypertension? / Versaci, Francesco; Sciarretta, Sebastiano; Scappaticci, Massimiliano; Calcagno, Simone; di Pietro, Riccardo; Sbandi, Francesca; Dei Giudici, Angela; Del Prete, Armando; de Angelis, Stefano; Biondi-Zoccai, Giuseppe. - In: EUROPEAN HEART JOURNAL SUPPLEMENTS. - ISSN 1520-765X. - 22:Suppl L(2020), pp. L160-L165-L165. [10.1093/eurheartj/suaa158]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1474414
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