Glial cell line-derived neurotrophic factor (GDNF) is a soluble molecule crucial for the regulation of the spermatogonial stem cells (SSC) of the testis. The effects of GDNF on target cells have been extensively described, but mechanisms underlying GDNF regulation are currently under investigation. In the nervous system, GDNF expression is regulated by pro-inflammatory cytokines including lipopolysaccharide (LPS), interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) but the effect of these cytokines on GDNF expression in the testis is unclear.

TNF-α inhibits GDNF levels in Sertoli cells, through a NF-κB-dependent, HES1-dependent mechanism / Di Persio, Sara; Starace, Donatella; Capponi, Chiara; Saracino, Rossana; Fera, Stefania; Filippini, Antonio; Vicini, Elena. - In: ANDROLOGY. - ISSN 2047-2919. - 9:3(2021), pp. 956-964. [10.1111/andr.12959]

TNF-α inhibits GDNF levels in Sertoli cells, through a NF-κB-dependent, HES1-dependent mechanism

Di Persio, Sara;Starace, Donatella;Capponi, Chiara;Saracino, Rossana;Fera, Stefania;Filippini, Antonio;Vicini, Elena
2021

Abstract

Glial cell line-derived neurotrophic factor (GDNF) is a soluble molecule crucial for the regulation of the spermatogonial stem cells (SSC) of the testis. The effects of GDNF on target cells have been extensively described, but mechanisms underlying GDNF regulation are currently under investigation. In the nervous system, GDNF expression is regulated by pro-inflammatory cytokines including lipopolysaccharide (LPS), interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) but the effect of these cytokines on GDNF expression in the testis is unclear.
2021
GDNF; HES1; NF-κB; sertoli cells; TNF-α
01 Pubblicazione su rivista::01a Articolo in rivista
TNF-α inhibits GDNF levels in Sertoli cells, through a NF-κB-dependent, HES1-dependent mechanism / Di Persio, Sara; Starace, Donatella; Capponi, Chiara; Saracino, Rossana; Fera, Stefania; Filippini, Antonio; Vicini, Elena. - In: ANDROLOGY. - ISSN 2047-2919. - 9:3(2021), pp. 956-964. [10.1111/andr.12959]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1473282
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