Glial cell line-derived neurotrophic factor (GDNF) is a soluble molecule crucial for the regulation of the spermatogonial stem cells (SSC) of the testis. The effects of GDNF on target cells have been extensively described, but mechanisms underlying GDNF regulation are currently under investigation. In the nervous system, GDNF expression is regulated by pro-inflammatory cytokines including lipopolysaccharide (LPS), interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) but the effect of these cytokines on GDNF expression in the testis is unclear.
TNF-α inhibits GDNF levels in Sertoli cells, through a NF-κB-dependent, HES1-dependent mechanism / Di Persio, Sara; Starace, Donatella; Capponi, Chiara; Saracino, Rossana; Fera, Stefania; Filippini, Antonio; Vicini, Elena. - In: ANDROLOGY. - ISSN 2047-2919. - 9:3(2021), pp. 956-964. [10.1111/andr.12959]
TNF-α inhibits GDNF levels in Sertoli cells, through a NF-κB-dependent, HES1-dependent mechanism
Di Persio, Sara;Starace, Donatella;Capponi, Chiara;Saracino, Rossana;Fera, Stefania;Filippini, Antonio;Vicini, Elena
2021
Abstract
Glial cell line-derived neurotrophic factor (GDNF) is a soluble molecule crucial for the regulation of the spermatogonial stem cells (SSC) of the testis. The effects of GDNF on target cells have been extensively described, but mechanisms underlying GDNF regulation are currently under investigation. In the nervous system, GDNF expression is regulated by pro-inflammatory cytokines including lipopolysaccharide (LPS), interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) but the effect of these cytokines on GDNF expression in the testis is unclear.| File | Dimensione | Formato | |
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Di persio_TNF-α-inhibits_2021.pdf
Open Access dal 02/01/2022
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