Attention Deficit/Hyperactivity Disorder (ADHD) is the most common neuro-developmental alteration in childhood. To date, its diagnosis is exclusively clinical, however recent studies focused on searching for objective biomarkers. We recently reported a selective alteration of DNA methylation in the 5′-UTR of dopamine transporter (DAT1) gene, in a 1CGG2CGG3CGG and a 5CG6CG motif, for ADHD patients (compared to controls). Presently, we looked for DNA methylation of the corresponding CpG sites but complementary on the opposite strand (“COS”). Exploiting a novel cross-correlation approach, we found a core M5 - M5 COS and M2 - M2 COS relationship with relatively free M1 and M6 COS extremes. Our data might be relevant, to find a new biomarker to diagnose ADHD in affected subjects.
Search for an epigenetic biomarker in ADHD diagnosis, based on the DAT1 gene 5’-UTR methylation. A new possible approach / Lambacher, G.; Pascale, E.; Pucci, M.; Mangiapelo, S.; D'Addario, C.; Adriani, W.. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - 291:(2020). [10.1016/j.psychres.2020.113154]
Search for an epigenetic biomarker in ADHD diagnosis, based on the DAT1 gene 5’-UTR methylation. A new possible approach
Pascale E.;
2020
Abstract
Attention Deficit/Hyperactivity Disorder (ADHD) is the most common neuro-developmental alteration in childhood. To date, its diagnosis is exclusively clinical, however recent studies focused on searching for objective biomarkers. We recently reported a selective alteration of DNA methylation in the 5′-UTR of dopamine transporter (DAT1) gene, in a 1CGG2CGG3CGG and a 5CG6CG motif, for ADHD patients (compared to controls). Presently, we looked for DNA methylation of the corresponding CpG sites but complementary on the opposite strand (“COS”). Exploiting a novel cross-correlation approach, we found a core M5 - M5 COS and M2 - M2 COS relationship with relatively free M1 and M6 COS extremes. Our data might be relevant, to find a new biomarker to diagnose ADHD in affected subjects.File | Dimensione | Formato | |
---|---|---|---|
Lambacher_preprint_Search_2020.pdf
accesso aperto
Tipologia:
Documento in Pre-print (manoscritto inviato all'editore, precedente alla peer review)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
744.9 kB
Formato
Adobe PDF
|
744.9 kB | Adobe PDF | |
Lambacher_Search_2020.pdf
solo gestori archivio
Note: https://www.sciencedirect.com/science/article/pii/S0165178120307757
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
157.69 kB
Formato
Adobe PDF
|
157.69 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.