Introduction: We aimed at exploring the proportion of patients dying with COVID-19 and concomitant dementia in Italy, as well as their clinical characteristics and trajectories of care. Methods: The proportion of COVID-19-related deaths occurring in people with dementia and the clinical characteristics of deceased individuals according to their dementia status were explored by considering the medical charts of a representative sample of patients deceased in Italian hospitals (n = 2621). Results: A total of 415 individuals with dementia were identified in the study population, accounting for 15.8% of overall COVID-19-related deaths. Patients with dementia less frequently presented with cough, had lower chance of receiving supportive therapies and intensive care approaches, and showed a faster clinical worsening as compared with individuals with intact cognition. Discussion: Dementia confers a relevant risk of adverse outcomes in case of SARS-CoV-2 infection and influences the clinical presentation, course and management of affected individuals.

Prevalence and clinical correlates of dementia among COVID-19-related deaths in Italy / Canevelli, Marco; Palmieri, Luigi; Raparelli, Valeria; Lo Noce, Cinzia; Colaizzo, Elisa; Tiple, Dorina; Vaianella, Luana; Vanacore, Nicola; Brusaferro, Silvio; Onder, Graziano. - In: ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING. - ISSN 2352-8729. - 12:1(2020). [10.1002/dad2.12114]

Prevalence and clinical correlates of dementia among COVID-19-related deaths in Italy

Canevelli, Marco
;
Palmieri, Luigi;Raparelli, Valeria;Colaizzo, Elisa;Vanacore, Nicola;Brusaferro, Silvio;Onder, Graziano
2020

Abstract

Introduction: We aimed at exploring the proportion of patients dying with COVID-19 and concomitant dementia in Italy, as well as their clinical characteristics and trajectories of care. Methods: The proportion of COVID-19-related deaths occurring in people with dementia and the clinical characteristics of deceased individuals according to their dementia status were explored by considering the medical charts of a representative sample of patients deceased in Italian hospitals (n = 2621). Results: A total of 415 individuals with dementia were identified in the study population, accounting for 15.8% of overall COVID-19-related deaths. Patients with dementia less frequently presented with cough, had lower chance of receiving supportive therapies and intensive care approaches, and showed a faster clinical worsening as compared with individuals with intact cognition. Discussion: Dementia confers a relevant risk of adverse outcomes in case of SARS-CoV-2 infection and influences the clinical presentation, course and management of affected individuals.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1472653
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