The purpose of this study was to investigate MRI features of triple-negative breast cancer (TNBC) compared with non-TNBC, to predict histopathological results. In the study, 26 patients with TNBC and 24 with non-TNBC who underwent multiparametric MRI of the breast on a 3 T magnet over a 10-months period were retrospectively recruited. MR imaging sets were evaluated by two experienced breast radiologists in consensus and classified according to the 2013 American College of Radiology (ACR) BI-RADS lexicon. The comparison between the two groups was performed using the Chi-square test and followed by logistic regression analyses. We found that 92% of tumors presented as mass enhancements (p = 0.192). 41.7% of TNBC and 86.4% of non-TNBC had irregular shape (p = 0.005); 58.3% of TNBC showed circumscribed margins, compared to 9.1% of non-TNBC masses (p = 0.001); 75% of TNBC and 9.1% of non-TNBC showed rim enhancement (p < 0.001). Intralesional necrosis was significantly associated with TNBC (p = 0.016). Rim enhancement and intralesional necrosis risulted to be positive predictors at univariate analysis (OR = 29.86, and 8.10, respectively) and the multivariate analysis confirmed that rim enhancement is independently associated with TNBC (OR = 33.08). The mean ADC values were significantly higher for TNBC (p = 0.011). In conclusion, TNBC is associated with specific MRI features that can be possible predictors of pathological results, with a consequent prognostic value.

Can MRI biomarkers predict triple-negative breast cancer? / Moffa, Giuliana; Galati, Francesca; Collalunga, Emmanuel; Rizzo, Veronica; Kripa, Endi; D'Amati, Giulia; Pediconi, Federica. - In: DIAGNOSTICS. - ISSN 2075-4418. - 10:12(2020), pp. 1-11. [10.3390/diagnostics10121090]

Can MRI biomarkers predict triple-negative breast cancer?

Moffa, Giuliana
Primo
;
Galati, Francesca
Secondo
;
Rizzo, Veronica;D'Amati, Giulia
Penultimo
;
Pediconi, Federica
Ultimo
2020

Abstract

The purpose of this study was to investigate MRI features of triple-negative breast cancer (TNBC) compared with non-TNBC, to predict histopathological results. In the study, 26 patients with TNBC and 24 with non-TNBC who underwent multiparametric MRI of the breast on a 3 T magnet over a 10-months period were retrospectively recruited. MR imaging sets were evaluated by two experienced breast radiologists in consensus and classified according to the 2013 American College of Radiology (ACR) BI-RADS lexicon. The comparison between the two groups was performed using the Chi-square test and followed by logistic regression analyses. We found that 92% of tumors presented as mass enhancements (p = 0.192). 41.7% of TNBC and 86.4% of non-TNBC had irregular shape (p = 0.005); 58.3% of TNBC showed circumscribed margins, compared to 9.1% of non-TNBC masses (p = 0.001); 75% of TNBC and 9.1% of non-TNBC showed rim enhancement (p < 0.001). Intralesional necrosis was significantly associated with TNBC (p = 0.016). Rim enhancement and intralesional necrosis risulted to be positive predictors at univariate analysis (OR = 29.86, and 8.10, respectively) and the multivariate analysis confirmed that rim enhancement is independently associated with TNBC (OR = 33.08). The mean ADC values were significantly higher for TNBC (p = 0.011). In conclusion, TNBC is associated with specific MRI features that can be possible predictors of pathological results, with a consequent prognostic value.
3 T MRI; DWI; breast cancer prognostic factors; triple-negative breast cancer
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Can MRI biomarkers predict triple-negative breast cancer? / Moffa, Giuliana; Galati, Francesca; Collalunga, Emmanuel; Rizzo, Veronica; Kripa, Endi; D'Amati, Giulia; Pediconi, Federica. - In: DIAGNOSTICS. - ISSN 2075-4418. - 10:12(2020), pp. 1-11. [10.3390/diagnostics10121090]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1472626
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