Background: It is a common opinion that Primary Sjögren Syndrome (pSS) damages the exocrine glands and determines the reduction of secreted saliva, some studies show that there are qualitative anomalies of the mucins produced in saliva, including MUC7, MUC5B, MUC1. The purpose of this study is to trace all the information useful to establish whether there is a qualitative or quantitative defect of the mucins in the pSS. Material and Methods: We reviewed the literature by looking for publications relevant to the topic in electronic databases. Sixteen articles met the search criteria. The studies were divided into two categories, those that studied the rheological characteristics of the saliva and those that studied the structural and / or metabolism modifications of the muciparous cells in the salivary glands. Results: in Patients with pSS, xerostomia and the reduction of salivary spinnbarkeit are only partially related to the reduction of the unstimulated salivary flow. In pSS, pathological alterations of mucins’ chemical-physical properties prevail as a cause of the clinical characteristics. Moreover, in pSS there are structural and metabolism changes in salivary glands’ muciparous cells. Conclusions: There is much evidence that supports the presence of qualitative alterations in the saliva’s rheological properties in Patients with pSS, and these are the main cause, more than the reduction of the unstimulated salivary flow, of the disease clinical characteristics - dry mouth and complications in the oral cavity. Therefore we propose to add to the classification criteria of pSS also a qualitative test of salivary glycoproteins.

Qualitative mucin disorders in patients with primary Sjögren's syndrome: a literature review / Fusconi, Massimo; Candelori, Francesca; Weiss, Lior; Riccio, Annachiara; Priori, Roberta; Businaro, Rita; Mastromanno, Linda; Musy, Isotta; DE VINCENTIIS, Marco; Greco, Antonio. - In: MEDICINA ORAL, PATOLOGÍA ORAL Y CIRUGÍA BUCAL. - ISSN 1698-4447. - 26:1(2021), pp. 71-77. [10.4317/medoral.23996]

Qualitative mucin disorders in patients with primary Sjögren's syndrome: a literature review

Massimo Fusconi
Primo
Project Administration
;
Francesca Candelori
Secondo
Writing – Original Draft Preparation
;
Roberta Priori
Visualization
;
Rita Businaro
Formal Analysis
;
Marco de Vincentiis
Penultimo
Supervision
;
Antonio Greco
Ultimo
Project Administration
2021

Abstract

Background: It is a common opinion that Primary Sjögren Syndrome (pSS) damages the exocrine glands and determines the reduction of secreted saliva, some studies show that there are qualitative anomalies of the mucins produced in saliva, including MUC7, MUC5B, MUC1. The purpose of this study is to trace all the information useful to establish whether there is a qualitative or quantitative defect of the mucins in the pSS. Material and Methods: We reviewed the literature by looking for publications relevant to the topic in electronic databases. Sixteen articles met the search criteria. The studies were divided into two categories, those that studied the rheological characteristics of the saliva and those that studied the structural and / or metabolism modifications of the muciparous cells in the salivary glands. Results: in Patients with pSS, xerostomia and the reduction of salivary spinnbarkeit are only partially related to the reduction of the unstimulated salivary flow. In pSS, pathological alterations of mucins’ chemical-physical properties prevail as a cause of the clinical characteristics. Moreover, in pSS there are structural and metabolism changes in salivary glands’ muciparous cells. Conclusions: There is much evidence that supports the presence of qualitative alterations in the saliva’s rheological properties in Patients with pSS, and these are the main cause, more than the reduction of the unstimulated salivary flow, of the disease clinical characteristics - dry mouth and complications in the oral cavity. Therefore we propose to add to the classification criteria of pSS also a qualitative test of salivary glycoproteins.
2021
primary Sjögren's syndrome; mucin; MUC7; MUC5B; MUC1; sulphate oligosaccharides
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Qualitative mucin disorders in patients with primary Sjögren's syndrome: a literature review / Fusconi, Massimo; Candelori, Francesca; Weiss, Lior; Riccio, Annachiara; Priori, Roberta; Businaro, Rita; Mastromanno, Linda; Musy, Isotta; DE VINCENTIIS, Marco; Greco, Antonio. - In: MEDICINA ORAL, PATOLOGÍA ORAL Y CIRUGÍA BUCAL. - ISSN 1698-4447. - 26:1(2021), pp. 71-77. [10.4317/medoral.23996]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1471309
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