Cardiac remodelling refers to molecular and cellular changes of the myocardium, as well as adapting altera tions i nsi ze, sha pe and fun cti on of the he art in res the final common pathway of different heart diseases, and is recognized as a crucial aspect of cardiac and myocardial dysfunction and a well established determinant of the clinical course of heart failure. ponse to ch and distribution anging loadi ng condi tions. It represents Osteopontin is an extracellular matrix glycoprotein secreted by osteoblasts, osteoclasts, macrophages, T cells, vascular smooth muscle cells, fibroblasts and cardiomyocytes. Osteopontin is not expressed in healthy cardiac tissue, although its expression can be triggered by pressure or volume overload, hypoxia and angiotensin II. Indeed, osteopontin has been reported in macrophages and interstitial tissues early after is prohibited. myocardial infarction and in cardiac macrophage-like cells of inflammatory lesions in experimental models of cardiomyopathy. Pressure overload is associated with osteopontin overexpression as well. Indeed, myocardial osteopontin messenger RNA is upregulated in rats following renovascular hypertension or aortic banding. In humans, a significant correlation exists between increased osteopontin immunoreactivity in cardiac myocytes and impaired left ventricular function or cardiomyocyte hypertrophy in patients with dilated cardiomyopathy. The present article focuses on the role of osteopontin in myocardial hypertrophy and remodelling. In general, evidence supports the concept that osteopontin plays a crucial role in extracellular matrix re- modelling following myocardial adaptation to hypertrophic, inflammatory and neurohormonal stimuli in the overloaded heart.

Extracellular matrix remodelling in myocardial hypertrophy and failure: focus on osteopontin / Francia, Pietro; Arianna, Uccellini; Alessandra, Frattari; Anna, Modestino; Agnese, Ricotta; Balla, Cristina; Ludovica, Scialla; Volpe, Massimo. - In: HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION. - ISSN 1120-9879. - STAMPA. - 16:4(2009), pp. 195-199. [10.2165/11530450-000000000-00000]

Extracellular matrix remodelling in myocardial hypertrophy and failure: focus on osteopontin

FRANCIA, Pietro;BALLA, CRISTINA;VOLPE, Massimo
2009

Abstract

Cardiac remodelling refers to molecular and cellular changes of the myocardium, as well as adapting altera tions i nsi ze, sha pe and fun cti on of the he art in res the final common pathway of different heart diseases, and is recognized as a crucial aspect of cardiac and myocardial dysfunction and a well established determinant of the clinical course of heart failure. ponse to ch and distribution anging loadi ng condi tions. It represents Osteopontin is an extracellular matrix glycoprotein secreted by osteoblasts, osteoclasts, macrophages, T cells, vascular smooth muscle cells, fibroblasts and cardiomyocytes. Osteopontin is not expressed in healthy cardiac tissue, although its expression can be triggered by pressure or volume overload, hypoxia and angiotensin II. Indeed, osteopontin has been reported in macrophages and interstitial tissues early after is prohibited. myocardial infarction and in cardiac macrophage-like cells of inflammatory lesions in experimental models of cardiomyopathy. Pressure overload is associated with osteopontin overexpression as well. Indeed, myocardial osteopontin messenger RNA is upregulated in rats following renovascular hypertension or aortic banding. In humans, a significant correlation exists between increased osteopontin immunoreactivity in cardiac myocytes and impaired left ventricular function or cardiomyocyte hypertrophy in patients with dilated cardiomyopathy. The present article focuses on the role of osteopontin in myocardial hypertrophy and remodelling. In general, evidence supports the concept that osteopontin plays a crucial role in extracellular matrix re- modelling following myocardial adaptation to hypertrophic, inflammatory and neurohormonal stimuli in the overloaded heart.
2009
cardiac remodelling; extracellular matrix; heart failure; osteopontin
01 Pubblicazione su rivista::01a Articolo in rivista
Extracellular matrix remodelling in myocardial hypertrophy and failure: focus on osteopontin / Francia, Pietro; Arianna, Uccellini; Alessandra, Frattari; Anna, Modestino; Agnese, Ricotta; Balla, Cristina; Ludovica, Scialla; Volpe, Massimo. - In: HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION. - ISSN 1120-9879. - STAMPA. - 16:4(2009), pp. 195-199. [10.2165/11530450-000000000-00000]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/147108
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 5
  • ???jsp.display-item.citation.isi??? ND
social impact