Mixed cationic liposomes composed by different ratios of dimyristoyl-sn-glycero-phosphatidyl- coline (DMPC) and a cationic gemini surfactant have been studied by various physicochemical tools as vehicles for m-tetrahydroxyphenylchlorin (m-THPC), a photosensitizer used in photodynamic therapy. Entrapment and location of m-THPC within the lipid double layer have been evaluated by different techniques and the new formulations have been tested on a stabilized cell line from a human colon tumor, COLO206. A correlation between the physicochemical features of formulations and their efficiency as photosensitizers vector was found.
Inclusion of a photosensitizer in liposomes formed by DMPC/gemini surfactant: correlation between physico-chemical and biological features of the complexes / Cecilia, Bombelli; Caracciolo, Giulio; PIETRO DI, Profio; Marco, Diociaiuti; Paola, Luciani; Giovanna, Mancini; Claudio, Mazzucca; Manuela, Marra; Agnese, Molinari; Donato, Monti; Laura, Toccaceli; Mariano, Venanzi. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 48:(2005), pp. 4882-4891. [10.1021/jm050182d]
Inclusion of a photosensitizer in liposomes formed by DMPC/gemini surfactant: correlation between physico-chemical and biological features of the complexes
CARACCIOLO, Giulio;DONATO MONTI;
2005
Abstract
Mixed cationic liposomes composed by different ratios of dimyristoyl-sn-glycero-phosphatidyl- coline (DMPC) and a cationic gemini surfactant have been studied by various physicochemical tools as vehicles for m-tetrahydroxyphenylchlorin (m-THPC), a photosensitizer used in photodynamic therapy. Entrapment and location of m-THPC within the lipid double layer have been evaluated by different techniques and the new formulations have been tested on a stabilized cell line from a human colon tumor, COLO206. A correlation between the physicochemical features of formulations and their efficiency as photosensitizers vector was found.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
