The evaluation of the response to vaccination in patients with inborn errors of immunity is a tool to evaluate T-dependent and T-independent antibody residual function of B lymphocytes and it is part of the diagnostic definition for Common Variable Immune Deficiencies. Currently used classifications for Common Variable Immune Deficiencies patients are based on the frequency of B cell subsets, and have been proven as a valid instrument for identification of patients at higher risk of infectious and non-infectious complications. This 6-years period observational study delineated the measurement of specific IgA antibodies induced by a 23-valent pneumococcal polysaccharides vaccine by a standardized ELISA for the quantification of IgA antibodies to all 23 pneumococcal serotypes as an additional prognostic marker in 74 CVID patients. The inability to mount an IgA-mediated response against the pneumococcal polysaccharide antigens or the inability to maintain the antibody response over time identified poor IgA CVID responders with severe immunological impairment, great risk of co-morbidities, and poor prognosis. The division of CVID patient into specific IgA-non responders and IgA-responders discriminated better than other CVID classifications for infectious risk, while it overlapped for non-infectious complications. Our study suggested to add the evaluation of the antibody response by the 23-valent IgA assay in the clinical monitoring of CVID patients.

IGA antibody induced by immunization with pneumococcal polysaccharides is a prognostic tool in common variable immune deficiencies / Pulvirenti, F.; Milito, C.; Cavaliere, F. M.; Mezzaroma, I.; Cinetto, F.; Quinti, I.. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 11:(2020). [10.3389/fimmu.2020.01283]

IGA antibody induced by immunization with pneumococcal polysaccharides is a prognostic tool in common variable immune deficiencies

Pulvirenti F.;Milito C.;Cavaliere F. M.;Mezzaroma I.;Quinti I.
2020

Abstract

The evaluation of the response to vaccination in patients with inborn errors of immunity is a tool to evaluate T-dependent and T-independent antibody residual function of B lymphocytes and it is part of the diagnostic definition for Common Variable Immune Deficiencies. Currently used classifications for Common Variable Immune Deficiencies patients are based on the frequency of B cell subsets, and have been proven as a valid instrument for identification of patients at higher risk of infectious and non-infectious complications. This 6-years period observational study delineated the measurement of specific IgA antibodies induced by a 23-valent pneumococcal polysaccharides vaccine by a standardized ELISA for the quantification of IgA antibodies to all 23 pneumococcal serotypes as an additional prognostic marker in 74 CVID patients. The inability to mount an IgA-mediated response against the pneumococcal polysaccharide antigens or the inability to maintain the antibody response over time identified poor IgA CVID responders with severe immunological impairment, great risk of co-morbidities, and poor prognosis. The division of CVID patient into specific IgA-non responders and IgA-responders discriminated better than other CVID classifications for infectious risk, while it overlapped for non-infectious complications. Our study suggested to add the evaluation of the antibody response by the 23-valent IgA assay in the clinical monitoring of CVID patients.
2020
common variable immunodeficiency; pneumococcal polysaccharides vaccine; respiratory infection; S. pneumoniae; specific IgA antibodies
01 Pubblicazione su rivista::01a Articolo in rivista
IGA antibody induced by immunization with pneumococcal polysaccharides is a prognostic tool in common variable immune deficiencies / Pulvirenti, F.; Milito, C.; Cavaliere, F. M.; Mezzaroma, I.; Cinetto, F.; Quinti, I.. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 11:(2020). [10.3389/fimmu.2020.01283]
File allegati a questo prodotto
File Dimensione Formato  
Pulvirenti_IGA-antibody_2020.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 991.17 kB
Formato Adobe PDF
991.17 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1467158
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 13
social impact