The pharmacokinetics and the serum and testicular levels of the drug up to 120 h after the administration of one single dose (100 mg/kg body weight) of lonidamine to Sprague-Dawley rats have been studied. Results were highly variable, as previously reported, but a very good Linear correlation was found between the serum and the testicular levels, suggesting that, in the rat, and possibly in the human, testicular levels could be estimated based on the serum concentrations.
Analysis of lonidamine in rat serum and testis by high performance liquid chromatography / Grippa, E; Gatto, Mt; Leone, Mg; Tita, Beatrice; ADBEL HAQ, H; Vitalone, Annabella; Silvestrini, Bruno; Saso, Luciano. - In: BIOMEDICAL CHROMATOGRAPHY. - ISSN 1099-0801. - STAMPA. - 15:(2001), pp. 1-8.
Analysis of lonidamine in rat serum and testis by high performance liquid chromatography.
TITA, Beatrice;VITALONE, Annabella;SILVESTRINI, Bruno;SASO, Luciano
2001
Abstract
The pharmacokinetics and the serum and testicular levels of the drug up to 120 h after the administration of one single dose (100 mg/kg body weight) of lonidamine to Sprague-Dawley rats have been studied. Results were highly variable, as previously reported, but a very good Linear correlation was found between the serum and the testicular levels, suggesting that, in the rat, and possibly in the human, testicular levels could be estimated based on the serum concentrations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
