An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is not pathognomonic. The possibility of false positives or other calcitonin-secreting neuroendocrine neoplasms (NENs) should be considered. Serum calcitonin levels are generally assessed by immunoradiometric and chemiluminescent assays with high sensitivity and specificity; however, slightly moderately elevated levels could be attributable to various confounding factors. Calcitonin values >100 pg/mL are strongly suspicious of malignancy, whereas in patients with moderately elevated values (10-100 pg/mL) a stimulation test may be applied to improve diagnostic accuracy. Although the standard protocol and the best gender-specific cut-offs for calcium-stimulated calcitonin are still controversial, the fold of the calcitonin increase after stimulation seems to be more reliable. Patients with MTC show stimulated calcitonin values at least three to four times higher than the basal values, whereas calcitonin-secreting NENs can be distinguished from a C-cell disease by the absence of or of or

Endocrine Tumours. Calcitonin in thyroid and extra-thyroid neuroendocrine neoplasms. The two-faced Janus / Giannetta, E.; Guarnotta, V.; Altieri, B.; Sciammarella, C.; Guadagno, E.; Malandrino, P.; Puliani, G.; Feola, T.; Isidori, A. M.; Colao, A. A. L.; Faggiano, A.. - In: EUROPEAN JOURNAL OF ENDOCRINOLOGY. - ISSN 0804-4643. - 183:6(2020), pp. 197-215. [10.1530/EJE-20-0506]

Endocrine Tumours. Calcitonin in thyroid and extra-thyroid neuroendocrine neoplasms. The two-faced Janus

Giannetta E.
;
Puliani G.;Feola T.;Isidori A. M.;Faggiano A.
2020

Abstract

An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is not pathognomonic. The possibility of false positives or other calcitonin-secreting neuroendocrine neoplasms (NENs) should be considered. Serum calcitonin levels are generally assessed by immunoradiometric and chemiluminescent assays with high sensitivity and specificity; however, slightly moderately elevated levels could be attributable to various confounding factors. Calcitonin values >100 pg/mL are strongly suspicious of malignancy, whereas in patients with moderately elevated values (10-100 pg/mL) a stimulation test may be applied to improve diagnostic accuracy. Although the standard protocol and the best gender-specific cut-offs for calcium-stimulated calcitonin are still controversial, the fold of the calcitonin increase after stimulation seems to be more reliable. Patients with MTC show stimulated calcitonin values at least three to four times higher than the basal values, whereas calcitonin-secreting NENs can be distinguished from a C-cell disease by the absence of or of or
2020
biomarkers; tumor; calcitonin; calcitonin gene-related peptide; carcinoma, neuroendocrine; diagnosis, differential; endocrine gland neoplasms; false positive reactions; female; humans; janus kinases; male; middle aged; reference values; sensitivity and specificity; thyroid neoplasms
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Endocrine Tumours. Calcitonin in thyroid and extra-thyroid neuroendocrine neoplasms. The two-faced Janus / Giannetta, E.; Guarnotta, V.; Altieri, B.; Sciammarella, C.; Guadagno, E.; Malandrino, P.; Puliani, G.; Feola, T.; Isidori, A. M.; Colao, A. A. L.; Faggiano, A.. - In: EUROPEAN JOURNAL OF ENDOCRINOLOGY. - ISSN 0804-4643. - 183:6(2020), pp. 197-215. [10.1530/EJE-20-0506]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1465507
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