Background: NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. Methods: We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). According to the severity of the disease, we stratified COVID-19 subjects into severe and non-severe groups. Results: Compared to HDs, COVID-19 subjects showed higher percentages of NK CD57+ and CD56dim NK cells and lower percentages of NKT and CD56bright cells. In the severe group we found a significantly lower percentage of NKT cells. In a multiple logistic regression analysis, NKT cell was independently associated with the severity of the disease. Conclusions: The low percentage of NKT cells in peripheral blood of COVID-19 subjects and the independent association with the severity of the disease suggests a potential role of this subset.

Major reduction of NKT cells in patients with severe COVID-19 pneumonia / Zingaropoli, M. A.; Perri, V.; Pasculli, P.; Cogliati Dezza, F.; Nijhawan, P.; Savelloni, G.; La Torre, G.; D'Agostino, C.; Mengoni, F.; Lichtner, M.; Ciardi, M. R.; Mastroianni, C. M.. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 222:(2020), pp. 1-10. [10.1016/j.clim.2020.108630]

Major reduction of NKT cells in patients with severe COVID-19 pneumonia

Zingaropoli M. A.;Perri V.;Pasculli P.;Cogliati Dezza F.;Nijhawan P.;Savelloni G.;La Torre G.;Mengoni F.;Lichtner M.;Ciardi M. R.;Mastroianni C. M.
2020

Abstract

Background: NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. Methods: We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). According to the severity of the disease, we stratified COVID-19 subjects into severe and non-severe groups. Results: Compared to HDs, COVID-19 subjects showed higher percentages of NK CD57+ and CD56dim NK cells and lower percentages of NKT and CD56bright cells. In the severe group we found a significantly lower percentage of NKT cells. In a multiple logistic regression analysis, NKT cell was independently associated with the severity of the disease. Conclusions: The low percentage of NKT cells in peripheral blood of COVID-19 subjects and the independent association with the severity of the disease suggests a potential role of this subset.
2020
cd56bright; cd56dim; flow cytometry; immunophenotyping analysis; sars-cov-2
01 Pubblicazione su rivista::01a Articolo in rivista
Major reduction of NKT cells in patients with severe COVID-19 pneumonia / Zingaropoli, M. A.; Perri, V.; Pasculli, P.; Cogliati Dezza, F.; Nijhawan, P.; Savelloni, G.; La Torre, G.; D'Agostino, C.; Mengoni, F.; Lichtner, M.; Ciardi, M. R.; Mastroianni, C. M.. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 222:(2020), pp. 1-10. [10.1016/j.clim.2020.108630]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1465097
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