Schwann-like adipose-derived stem cells as a promising therapeutic tool for peripheral nerve regeneration: effects of cholinergic stimulation

Schwann-like adipose-derived stem cells and nerve injury: Peripheral nerve injuries (PNIs) are a common clinical problem usually as a consequence of trauma. Despite optimal surgical management, PNI has a lifelong impact on function and wellbeing of the patient. The peripheral nervous system (PNS) has regenerative capability, in contrast to the central nervous system (CNS), and is dependent on the plasticity of the peripheral glia, Schwann cells (SCs). Despite this regenerative capability, PNI recovery of sensorial and motor function is always incomplete causing pain, cold intolerance, paralysis and impairment of activities of daily living. Therefore, development of innovative approaches enhancing PNS regeneration after injury is of great clinical relevance (Faroni et al., 2015).