In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO(5) on oligonucleotides. We found that the three major products of guanine oxidation are formed by independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non-detected guanine oxidation products on oxidatively damaged DNA.
Guanine Oxidation in Double Stranded DNA by MnTMPyP/KHSO5: at Least Three independent Reaction Pathways / Lapi, Andrea; Pratviel, G; Meunier, B.. - In: METAL-BASED DRUGS. - ISSN 0793-0291. - STAMPA. - 8:(2001), pp. 47-56. [10.1155/MBD.2001.47]
Guanine Oxidation in Double Stranded DNA by MnTMPyP/KHSO5: at Least Three independent Reaction Pathways.
LAPI, Andrea;
2001
Abstract
In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO(5) on oligonucleotides. We found that the three major products of guanine oxidation are formed by independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non-detected guanine oxidation products on oxidatively damaged DNA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
