In recent years, developing potent antioxidants has been a very active area of research. In this context, phenolic compounds have been evaluated for their antioxidant activity. However, the use of phenolic compounds has also been limited by poor antioxidant activity in several in vivo studies. Polymeric phenols have received much attention owing to their potent antioxidant properties and increased stability in aqueous systems. To be truly effective in biological applications, it is important that these polymers be synthesized using benign methods. In this context, enzyme catalyzed synthesis of polymeric phenols has been explored as an environmentally friendly and safer approach. This review summarizes work in enzymatic syntheses of polymers of phenols. Several assays have been developed to determine the antioxidant potency of these polymeric phenols. These assays are discussed in detail along with structure-property relationships. A deeper understanding of factors affecting antioxidant activity would provide an opportunity for the design of versatile, high performing polymers with enhanced antioxidant activity.

Antioxidant activity of synthetic polymers of phenolic compounds / Nagarajan, Subhalakshmi; Nagarajan, Ramaswamy; Kumar, Jayant; Salemme, Adele; Togna, Anna Rita; Saso, Luciano; Bruno, Ferdinando. - In: POLYMERS. - ISSN 2073-4360. - 12:8(2020), pp. 1-27. [10.3390/polym12081646]

Antioxidant activity of synthetic polymers of phenolic compounds

Salemme, Adele;Togna, Anna Rita;Saso, Luciano;
2020

Abstract

In recent years, developing potent antioxidants has been a very active area of research. In this context, phenolic compounds have been evaluated for their antioxidant activity. However, the use of phenolic compounds has also been limited by poor antioxidant activity in several in vivo studies. Polymeric phenols have received much attention owing to their potent antioxidant properties and increased stability in aqueous systems. To be truly effective in biological applications, it is important that these polymers be synthesized using benign methods. In this context, enzyme catalyzed synthesis of polymeric phenols has been explored as an environmentally friendly and safer approach. This review summarizes work in enzymatic syntheses of polymers of phenols. Several assays have been developed to determine the antioxidant potency of these polymeric phenols. These assays are discussed in detail along with structure-property relationships. A deeper understanding of factors affecting antioxidant activity would provide an opportunity for the design of versatile, high performing polymers with enhanced antioxidant activity.
2020
antioxidant; synthetic polymers; phenolic compounds; pharmacology
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Antioxidant activity of synthetic polymers of phenolic compounds / Nagarajan, Subhalakshmi; Nagarajan, Ramaswamy; Kumar, Jayant; Salemme, Adele; Togna, Anna Rita; Saso, Luciano; Bruno, Ferdinando. - In: POLYMERS. - ISSN 2073-4360. - 12:8(2020), pp. 1-27. [10.3390/polym12081646]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1461456
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