Background. To compare the effects of a single intra-articular injection of low molecular weight hyaluronic acid (LMWHA) versus 3 injections of the same LMWHA in patients affected by rhizarthrosis. Methods. 40 patients received ultrasound (US) guided injections of LMW HA: Group A (20 patients) injections with 1 ml HA; Group B (20 patients) once a week for 3 times injections of 1 ml HA. Both groups were examined at baseline, at 1, 3 and 6 months follow-up using VAS (Visual Analogue Scale), Kapandji Thumb Opposition Test, DASH Score (func-tional assessment questionnaire) and DASH Work. Results. Patients treated with a single HA injection had a statistically significant improvement (p<0.05) of the VAS at 1-and 3-months follow-up compared to baseline, and of Kapandji thumb opposition test only at 6 months compared to baseline. Patients received 3 HA injections shown a statistically significant improvement (p< 0.05) of the VAS, DASH score, DASH-work and Kapandji thumb opposition test at 1, 3-and 6-months follow-up compared to baseline. The intergroup analysis did not underline any significant differences between the two groups at all follow-up. Conclusions. The intra-articular HA injections allowed good effects in patients suffering from rhizarthrosis. To have a low term pain relief a single injection can be used. The 3 injections protocol is more indicated if we want to obtain also a functional improvement.

Mind term effects of a single injection versus three injections of hyaluronic acid in patients with rhizarthrosis / Perugia, D.; Lanzetti, R. M.; Vetrano, M.; Vavala, C.; Pascali, S.; Nusca, S. M.; Santoboni, F.; Vulpiani, M. C.. - In: M.L.T.J. MUSCLES, LIGAMENTS AND TENDONS JOURNAL. - ISSN 2240-4554. - 10:1(2020), pp. 130-137. [10.32098/mltj.01.2020.18]

Mind term effects of a single injection versus three injections of hyaluronic acid in patients with rhizarthrosis

Perugia D.;Lanzetti R. M.;Vetrano M.;Vavala C.;Pascali S.;Nusca S. M.;Santoboni F.;Vulpiani M. C.
2020

Abstract

Background. To compare the effects of a single intra-articular injection of low molecular weight hyaluronic acid (LMWHA) versus 3 injections of the same LMWHA in patients affected by rhizarthrosis. Methods. 40 patients received ultrasound (US) guided injections of LMW HA: Group A (20 patients) injections with 1 ml HA; Group B (20 patients) once a week for 3 times injections of 1 ml HA. Both groups were examined at baseline, at 1, 3 and 6 months follow-up using VAS (Visual Analogue Scale), Kapandji Thumb Opposition Test, DASH Score (func-tional assessment questionnaire) and DASH Work. Results. Patients treated with a single HA injection had a statistically significant improvement (p<0.05) of the VAS at 1-and 3-months follow-up compared to baseline, and of Kapandji thumb opposition test only at 6 months compared to baseline. Patients received 3 HA injections shown a statistically significant improvement (p< 0.05) of the VAS, DASH score, DASH-work and Kapandji thumb opposition test at 1, 3-and 6-months follow-up compared to baseline. The intergroup analysis did not underline any significant differences between the two groups at all follow-up. Conclusions. The intra-articular HA injections allowed good effects in patients suffering from rhizarthrosis. To have a low term pain relief a single injection can be used. The 3 injections protocol is more indicated if we want to obtain also a functional improvement.
2020
Hyaluronic acid; Infiltration; Osteoarthritis; Rhizarthrosis
01 Pubblicazione su rivista::01a Articolo in rivista
Mind term effects of a single injection versus three injections of hyaluronic acid in patients with rhizarthrosis / Perugia, D.; Lanzetti, R. M.; Vetrano, M.; Vavala, C.; Pascali, S.; Nusca, S. M.; Santoboni, F.; Vulpiani, M. C.. - In: M.L.T.J. MUSCLES, LIGAMENTS AND TENDONS JOURNAL. - ISSN 2240-4554. - 10:1(2020), pp. 130-137. [10.32098/mltj.01.2020.18]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1460180
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