Purpose: To assess the diagnostic value of strain ratio elastography (SRE), a semiquantitative elastosonographic method based on the displacement of the tissue from an external source (manual compression with the transducer), as compared and in combination with conventional ultrasound for the differentiation of breast lesions. Methods: One hundred and eighty-two patients with breast lesions consecutively underwent B-mode, color Doppler US, and strain US-elastography. Each lesion was classified according to the BI-RADS lexicon by evaluating the size, the B-mode, and color Doppler features and then evaluated by SRE. Histology proven by biopsy was used as the gold standard and the patients with malignant lesions subsequently underwent operations. The diagnostic performance of each method was assessed with 2 × 2 contingency tables and ROC curve analysis. To maximize the SRE sensitivity and specificity, the SRE cut-off value was calculated using the Youden test. Results: Histological examination revealed 66 benign and 116 malignant breast lesions. The conventional ultrasound showed sensitivity and specificity for the differentiation of benign and malignant lesions of 86.2% and 75.8%, respectively. Similar results were found for strain US-elastography with a cut-off of 2.49, with sensitivity and specificity of 89.7% and 72.7%, respectively. The association of conventional ultrasound with the SRE value increased the sensitivity (98.3%) but decreased the specificity compared with conventional US alone (63.6%). Conclusion: Strain US-elastography can be associated with BI-RADS US examination. According to our preliminary results, it helped increase the sensitivity although it decreased the specificity. However, further multicenter studies on a larger population are warranted.

Can strain US-elastography with strain ratio (SRE) improve the diagnostic accuracy in the assessment of breast lesions? Preliminary results / Elia, D.; Fresilli, D.; Pacini, P.; Cardaccio, S.; Polti, G.; Guiban, O.; Celletti, I.; Kutrolli, E.; De Felice, C.; Occhiato, R.; De Vito, C.; Amabile, M. I.; De Luca, A.; D'Andrea, V.; Vergine, M.; Pediconi, F.; D'Ambrosio, F.; Cantisani, V.. - In: JOURNAL OF ULTRASOUND. - ISSN 1971-3495. - (2020). [10.1007/s40477-020-00505-3]

Can strain US-elastography with strain ratio (SRE) improve the diagnostic accuracy in the assessment of breast lesions? Preliminary results

Elia D.
Primo
;
Fresilli D.
Secondo
;
Pacini P.;Cardaccio S.;Polti G.;Guiban O.;Celletti I.;Kutrolli E.;De Felice C.;Occhiato R.;De Vito C.;Amabile M. I.;De Luca A.;D'Andrea V.;Vergine M.;Pediconi F.;D'Ambrosio F.
Penultimo
;
Cantisani V.
Ultimo
2020

Abstract

Purpose: To assess the diagnostic value of strain ratio elastography (SRE), a semiquantitative elastosonographic method based on the displacement of the tissue from an external source (manual compression with the transducer), as compared and in combination with conventional ultrasound for the differentiation of breast lesions. Methods: One hundred and eighty-two patients with breast lesions consecutively underwent B-mode, color Doppler US, and strain US-elastography. Each lesion was classified according to the BI-RADS lexicon by evaluating the size, the B-mode, and color Doppler features and then evaluated by SRE. Histology proven by biopsy was used as the gold standard and the patients with malignant lesions subsequently underwent operations. The diagnostic performance of each method was assessed with 2 × 2 contingency tables and ROC curve analysis. To maximize the SRE sensitivity and specificity, the SRE cut-off value was calculated using the Youden test. Results: Histological examination revealed 66 benign and 116 malignant breast lesions. The conventional ultrasound showed sensitivity and specificity for the differentiation of benign and malignant lesions of 86.2% and 75.8%, respectively. Similar results were found for strain US-elastography with a cut-off of 2.49, with sensitivity and specificity of 89.7% and 72.7%, respectively. The association of conventional ultrasound with the SRE value increased the sensitivity (98.3%) but decreased the specificity compared with conventional US alone (63.6%). Conclusion: Strain US-elastography can be associated with BI-RADS US examination. According to our preliminary results, it helped increase the sensitivity although it decreased the specificity. However, further multicenter studies on a larger population are warranted.
2020
BI-RADS; breast lesions; strain ratio; strain US-elastography; ultrasound
01 Pubblicazione su rivista::01a Articolo in rivista
Can strain US-elastography with strain ratio (SRE) improve the diagnostic accuracy in the assessment of breast lesions? Preliminary results / Elia, D.; Fresilli, D.; Pacini, P.; Cardaccio, S.; Polti, G.; Guiban, O.; Celletti, I.; Kutrolli, E.; De Felice, C.; Occhiato, R.; De Vito, C.; Amabile, M. I.; De Luca, A.; D'Andrea, V.; Vergine, M.; Pediconi, F.; D'Ambrosio, F.; Cantisani, V.. - In: JOURNAL OF ULTRASOUND. - ISSN 1971-3495. - (2020). [10.1007/s40477-020-00505-3]
File allegati a questo prodotto
File Dimensione Formato  
Elia_Can-strain_2020.pdf

solo gestori archivio

Note: https://doi.org/10.1007/s40477-020-00505-3
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.28 MB
Formato Adobe PDF
1.28 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1459890
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact