Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic IRI can seriously impair liver function, even producing irreversible damage, which causes a cascade of multiple organ dysfunc- tion. Many factors, including anaerobic metabolism, mitochondrial damage, oxidative stress and secre- tion of ROS, intracellular Ca2þ overload, cytokines and chemokines produced by KCs and neutrophils, and NO, are involved in the regulation of hepatic IRI processes. Matrix Metalloproteinases (MMPs) can be an important mediator of early leukocyte recruitment and target in acute and chronic liver injury associated to ischemia. MMPs and neutrophil gelatinase- associated lipocalin (NGAL) could be used as markers of I-R injury severity stages. This review explores the relationship between factors and inflammatory pathways that characterize hepatic IRI, MMPs and current pharmacological approaches to this disease

Hepatic ischemia reperfusion injury: a systematic review of literature and the role of current drugs and biomarkers. J / Cannistrà, M; Ruggiero, M; Zullo, A; Gallelli, G; Serafini, S; Mazzitelli, M; Naso, A; Grande, R; Serra, R; Nardo, B.. - In: INTERNATIONAL JOURNAL OF SURGERY. - ISSN 1743-9159. - (2016). [10.1016/j.ijsu.2016.05.050]

Hepatic ischemia reperfusion injury: a systematic review of literature and the role of current drugs and biomarkers. J

Grande R;
2016

Abstract

Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic IRI can seriously impair liver function, even producing irreversible damage, which causes a cascade of multiple organ dysfunc- tion. Many factors, including anaerobic metabolism, mitochondrial damage, oxidative stress and secre- tion of ROS, intracellular Ca2þ overload, cytokines and chemokines produced by KCs and neutrophils, and NO, are involved in the regulation of hepatic IRI processes. Matrix Metalloproteinases (MMPs) can be an important mediator of early leukocyte recruitment and target in acute and chronic liver injury associated to ischemia. MMPs and neutrophil gelatinase- associated lipocalin (NGAL) could be used as markers of I-R injury severity stages. This review explores the relationship between factors and inflammatory pathways that characterize hepatic IRI, MMPs and current pharmacological approaches to this disease
2016
Hepatic ischemia reperfusion injury Preconditioning Inflammation Metalloproteinases
01 Pubblicazione su rivista::01a Articolo in rivista
Hepatic ischemia reperfusion injury: a systematic review of literature and the role of current drugs and biomarkers. J / Cannistrà, M; Ruggiero, M; Zullo, A; Gallelli, G; Serafini, S; Mazzitelli, M; Naso, A; Grande, R; Serra, R; Nardo, B.. - In: INTERNATIONAL JOURNAL OF SURGERY. - ISSN 1743-9159. - (2016). [10.1016/j.ijsu.2016.05.050]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1457772
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