Chronic Venous Ulceration of the lower limbs and Thrombosis.

Chronic venous ulceration is a major complication of chronic venous disorder with important implications in terms of mor- bidity and social expenditure. Venous thrombosis and throm- bophilia are widespread conditions, often associated with venous ulcers of the lower limbs. This link has not yet been widely described in the literature and aim of this work was to analyze the relationship between these two conditions review- ing the current literature. PubMed, Scopus and ScienceDirect databases were searched for articles using the terms: throm- bophilia, venous ulceration, chronic venous disorders and the significant full text were downloaded and analyzed. From the literature review, a description of the most common throm- bofilic abnormalities found in literature and the relation- ship with CVU was given. Conditions such as antithrombin deficiency, protein C deficiency, protein S deficiency, factor V Leiden, hyperhomocystinaemia, prothrombin G20210A mutation, antiphospholipid antibodies, elevated factor VIII levels, elevated factor XI levels, plasminogen activator inhibi- tor type 1 mutations, cancer, obesity, pregnancy and trauma through current literature were statistically linked to the presence of chronic venous ulceration. The main conclusion to be drawn from the available literature is that patients with chronic venous ulceration of the lower limbs appear to have a prevalence of thrombophilia and/or thromboembolic events that is much higher than in the general population