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EnglishBackground: We aimed to validate Imamura nomogram for prediction of stone free rate in patients undergoing ureterolithotripsy (ULT). Methods: From January 2013 to June 2016, patients undergoing laser semi-rigid ULT were prospectively enrolled at our center. All patients were preoperatively assessed with clinical history, blood samples, uranalysis and non-contrast enhanced computed tomography (CT). Treatment efficacy was assessed 1 month later by non-contrast enhanced CT. ROC curve was used to evaluate the performance characteristics of Imamura nomogram. Results: Overall, we enrolled 275 patients. Median age was 55 years (IQR: 46/64), median length of stone was 9.8 mm (IQR: 7.5/12). Pyuria was detected in 6/275 (2.1%) patients. Stones were located at ureteropelvic junction in 55/275 (19%) patients, proximal ureter in 74/275 (26%) patients, middle and distal ureter in 66/275 (24%) patients and 82/275 (30%) patients, respectively. At 1-month follow-up, 209/275 (76%) patients were stone free. Imamura nomogram presented an AUC of 0.67 (95% CI: 0.580-0.761) for the prediction of stone free rate. At the best cut-off value of 75%, sensitivity was 76%, specificity was 55%, positive predictive value (PPV) was 83% and negative predictive value was 45%. Conclusions: We firstly validated Imamura nomogram in a European cohort study. It proved a reasonable accuracy (area under curve: 0.67) and a good PPV (83%). Further studies should confirm our results to support the routine clinical use of Imamura nomogram as a tool to predict ULT outcomes.
External validation of Imamura nomogram as a tool to predict preoperatively laser semi-rigid ureterolithotripsy outcomes / De Nunzio, C.; Bellangino, M.; Voglino, O. A.; Baldassarri, V.; Lombardo, R.; Pignatelli, M.; Tema, G.; Berardi, E.; Cremona, A.; Tubaro, A.. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 0393-2249. - 71:5(2019), pp. 531-536. [10.23736/S0393-2249.18.03243-5]
| Titolo: | External validation of Imamura nomogram as a tool to predict preoperatively laser semi-rigid ureterolithotripsy outcomes | |
| Autori: | ||
| Data di pubblicazione: | 2019 | |
| Rivista: | ||
| Citazione: | External validation of Imamura nomogram as a tool to predict preoperatively laser semi-rigid ureterolithotripsy outcomes / De Nunzio, C.; Bellangino, M.; Voglino, O. A.; Baldassarri, V.; Lombardo, R.; Pignatelli, M.; Tema, G.; Berardi, E.; Cremona, A.; Tubaro, A.. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 0393-2249. - 71:5(2019), pp. 531-536. [10.23736/S0393-2249.18.03243-5] | |
| Handle: | http://hdl.handle.net/11573/1457295 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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