The association in aqueous mixtures of a thermoresponsive cationic diblock copolymer composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(3-acrylamidopropyl)-trimethylammonium-chloride (PAMPTMA(+)) and the oppositely charged bile salt sodium deoxycholate (NaDC) is investigated at different compositions by light and X-ray scattering, calorimetry, and electrophoretic mobility measurements. Clouding reveals aggregation upon heating. The addition of NaDC to the copolymer solution lowers the temperature of the transition and increases its cooperativity. At high temperature and low NaDC fractions, mixed aggregates with a dehydrated PNIPAM-rich interior and a PAMPTMA(+)-rich shell partially neutralized by DC– anions are formed. At high NaDC fractions, the aggregates present internal regularly spaced segregated nanoregions of dehydrated PNIPAM and PAMPTMA(+)/DC– (microphase separation). The results suggest that the mixed aggregates have appealing composition-controlled thermoresponse. The system phase separates at body temperature and the highest NaDC fractions investigated, meaning in conditions accomplished when the use of the polymer as a bile salt sequestrant is hypothesized. © 2020 The Authors

Effect of temperature on the association behavior in aqueous mixtures of an oppositely charged amphiphilic block copolymer and bile salt / Du, Guanqun; Del Giudice, Alessandra; Alfredsson, Viveka; Carnerup, Anna M.; Pavel, Nicolae V.; Loh, Watson; Masci, Giancarlo; Nystrom, Bo; Galantini, Luciano; Schillen, Karin. - In: POLYMER. - ISSN 0032-3861. - 206:(2020). [10.1016/j.polymer.2020.122871]

Effect of temperature on the association behavior in aqueous mixtures of an oppositely charged amphiphilic block copolymer and bile salt

Del Giudice, Alessandra;Pavel, Nicolae V.;Masci, Giancarlo;Galantini, Luciano
;
2020

Abstract

The association in aqueous mixtures of a thermoresponsive cationic diblock copolymer composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(3-acrylamidopropyl)-trimethylammonium-chloride (PAMPTMA(+)) and the oppositely charged bile salt sodium deoxycholate (NaDC) is investigated at different compositions by light and X-ray scattering, calorimetry, and electrophoretic mobility measurements. Clouding reveals aggregation upon heating. The addition of NaDC to the copolymer solution lowers the temperature of the transition and increases its cooperativity. At high temperature and low NaDC fractions, mixed aggregates with a dehydrated PNIPAM-rich interior and a PAMPTMA(+)-rich shell partially neutralized by DC– anions are formed. At high NaDC fractions, the aggregates present internal regularly spaced segregated nanoregions of dehydrated PNIPAM and PAMPTMA(+)/DC– (microphase separation). The results suggest that the mixed aggregates have appealing composition-controlled thermoresponse. The system phase separates at body temperature and the highest NaDC fractions investigated, meaning in conditions accomplished when the use of the polymer as a bile salt sequestrant is hypothesized. © 2020 The Authors
oppositely charged polymer-surfactant systems; bile salts; cationic thermoresponsive block copolymers
01 Pubblicazione su rivista::01a Articolo in rivista
Effect of temperature on the association behavior in aqueous mixtures of an oppositely charged amphiphilic block copolymer and bile salt / Du, Guanqun; Del Giudice, Alessandra; Alfredsson, Viveka; Carnerup, Anna M.; Pavel, Nicolae V.; Loh, Watson; Masci, Giancarlo; Nystrom, Bo; Galantini, Luciano; Schillen, Karin. - In: POLYMER. - ISSN 0032-3861. - 206:(2020). [10.1016/j.polymer.2020.122871]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1457217
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