According to the 2018 GLOBOCAN database, colorectal cancer is one of the most common malignancies and leading causes of cancer-related death worldwide. During the last decades, considerable progress has been made in understanding the complex pathogenetic mechanisms involved in this neoplastic disease. Due to the need to improve treatment responses and clinical outcomes of colorectal cancer patients, the identification of new molecular biomarkers became a crucial spot in clinical oncology. As biological indicators of a specific pathological or physiological process, molecular markers play a central role in cancer detection, diagnosis, outcome prediction, and treatment choice. Considering the existing evidence that malignancies originating from distinct colonic regions behave differently, it is clear that specific biomarkers can be associated to right- or left-sided colon carcinomas, reflecting the distinct molecular signatures of these different tumor entities. The aim of this review is to summarize the main differences among tumors arising from proximal and distal colon in terms of current and emerging biomarkers.

According to the 2018 GLOBOCAN database, colorectal cancer is one of the most common malignancies and leading causes of cancer-related death worldwide. During the last decades, considerable progress has been made in understanding the complex pathogenetic mechanisms involved in this neoplastic disease. Due to the need to improve treatment responses and clinical outcomes of colorectal cancer patients, the identification of new molecular biomarkers became a crucial spot in clinical oncology. As biological indicators of a specific pathological or physiological process, molecular markers play a central role in cancer detection, diagnosis, outcome prediction, and treatment choice. Considering the existing evidence that malignancies originating from distinct colonic regions behave differently, it is clear that specific biomarkers can be associated to right-or left-sided colon carcinomas, reflecting the distinct molecular signatures of these different tumor entities. The aim of this review is to summarize the main differences among tumors arising from proximal and distal colon in terms of current and emerging biomarkers.

Molecular Biomarkers according to Primary Tumor Location in Colorectal Cancer: Current Standard and New Insights / De Renzi, Gianluigi; Gaballo, Giulio; Gazzaniga, Paola; Nicolazzo, Chiara. - In: ONCOLOGY. - ISSN 0030-2414. - 99:3(2021), pp. 135-143. [10.1159/000510944]

Molecular Biomarkers according to Primary Tumor Location in Colorectal Cancer: Current Standard and New Insights

De Renzi, Gianluigi
Primo
;
Gazzaniga, Paola
Penultimo
;
Nicolazzo, Chiara
Ultimo
2021

Abstract

According to the 2018 GLOBOCAN database, colorectal cancer is one of the most common malignancies and leading causes of cancer-related death worldwide. During the last decades, considerable progress has been made in understanding the complex pathogenetic mechanisms involved in this neoplastic disease. Due to the need to improve treatment responses and clinical outcomes of colorectal cancer patients, the identification of new molecular biomarkers became a crucial spot in clinical oncology. As biological indicators of a specific pathological or physiological process, molecular markers play a central role in cancer detection, diagnosis, outcome prediction, and treatment choice. Considering the existing evidence that malignancies originating from distinct colonic regions behave differently, it is clear that specific biomarkers can be associated to right-or left-sided colon carcinomas, reflecting the distinct molecular signatures of these different tumor entities. The aim of this review is to summarize the main differences among tumors arising from proximal and distal colon in terms of current and emerging biomarkers.
2021
According to the 2018 GLOBOCAN database, colorectal cancer is one of the most common malignancies and leading causes of cancer-related death worldwide. During the last decades, considerable progress has been made in understanding the complex pathogenetic mechanisms involved in this neoplastic disease. Due to the need to improve treatment responses and clinical outcomes of colorectal cancer patients, the identification of new molecular biomarkers became a crucial spot in clinical oncology. As biological indicators of a specific pathological or physiological process, molecular markers play a central role in cancer detection, diagnosis, outcome prediction, and treatment choice. Considering the existing evidence that malignancies originating from distinct colonic regions behave differently, it is clear that specific biomarkers can be associated to right- or left-sided colon carcinomas, reflecting the distinct molecular signatures of these different tumor entities. The aim of this review is to summarize the main differences among tumors arising from proximal and distal colon in terms of current and emerging biomarkers.
Biomarkers; Colorectal cancer; Liquid biopsy; Precision medicine; Sidedness; Biomarkers, Tumor; Colonic Neoplasms; Humans; Liquid Biopsy; Prognosis; Proto-Oncogene Proteins B-raf; ras Proteins; Microsatellite Instability
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Molecular Biomarkers according to Primary Tumor Location in Colorectal Cancer: Current Standard and New Insights / De Renzi, Gianluigi; Gaballo, Giulio; Gazzaniga, Paola; Nicolazzo, Chiara. - In: ONCOLOGY. - ISSN 0030-2414. - 99:3(2021), pp. 135-143. [10.1159/000510944]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1455309
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