The theoretical treatment of macrocyclization reactions under thermodynamic control is overviewed in the light of recent growing interest toward Dynamic Combinatorial Chemistry (DCC). The rules governing the equilibrium processes in Dynamic Library (DL) under conditions of perfect mass balance are illustrated. Data related to transacetalation reactions of cyclophane formaldehyde acetals are thoroughly discussed as remarkable examples of systems where experiments and theory make a good match. Copyright (C) 2010 John Wiley & Sons, Ltd.
Theoretical features of macrocyclization equilibria and their application on transacetalation based dynamic libraries / DI STEFANO, Stefano. - In: JOURNAL OF PHYSICAL ORGANIC CHEMISTRY. - ISSN 0894-3230. - 23:9(2010), pp. 797-805. [10.1002/poc.1674]
Theoretical features of macrocyclization equilibria and their application on transacetalation based dynamic libraries
DI STEFANO, Stefano
2010
Abstract
The theoretical treatment of macrocyclization reactions under thermodynamic control is overviewed in the light of recent growing interest toward Dynamic Combinatorial Chemistry (DCC). The rules governing the equilibrium processes in Dynamic Library (DL) under conditions of perfect mass balance are illustrated. Data related to transacetalation reactions of cyclophane formaldehyde acetals are thoroughly discussed as remarkable examples of systems where experiments and theory make a good match. Copyright (C) 2010 John Wiley & Sons, Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
