Abstract—Endocannabinoids have emerged as a new class of lipid mediators, with manifold roles in the central nervous system and in the periphery. Several studies have identified 2-arachidonoyl-glycerol (2-AG) as a major endogenous agonist of cannabinoid receptors. Here, the chemical synthesis of 2-AG is reported, along with the synthesis of its tritium-labeled derivative. These unlabeled and radiolabeled compounds are suitable tools for unravelling some metabolic routes and biological activities of 2-AG in various cells and tissues.
Simplified chemical and radiochemical synthesis of 2-arachidonoyl-glycerol, an endogenus ligand of cannabinoid receptors / Cartoni, Antonella; A., Margonelli; G., Angelini; A., FINAZZI AGRO'; M., Maccarrone. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 45:(2004), pp. 2723-2726. [10.1016/j.tetlet.2004.02.045]
Simplified chemical and radiochemical synthesis of 2-arachidonoyl-glycerol, an endogenus ligand of cannabinoid receptors
CARTONI, Antonella;
2004
Abstract
Abstract—Endocannabinoids have emerged as a new class of lipid mediators, with manifold roles in the central nervous system and in the periphery. Several studies have identified 2-arachidonoyl-glycerol (2-AG) as a major endogenous agonist of cannabinoid receptors. Here, the chemical synthesis of 2-AG is reported, along with the synthesis of its tritium-labeled derivative. These unlabeled and radiolabeled compounds are suitable tools for unravelling some metabolic routes and biological activities of 2-AG in various cells and tissues.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
