Radiogenomics in clear cell renal cell carcinoma: Correlations between advanced CT imaging (texture analysis) and microRNAs expression

A relevant challenge for the improvement of clear cell renal cell carcinoma management could derive from the identification of novel molecular biomarkers that could greatly improve the diagnosis, prognosis, and treatment choice of these neoplasms. In this study, we investigate whether quantitative parameters obtained from computed tomography texture analysis (CTTA) may correlate with the expression of selected oncogenic microRNAs (miRNA). To the best of our knowledge, a possible correlation between CT texture parameters and miRNAs expression in ccRCC was not investigated yet.