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EnglishBacterial infections have been on the rise world-wide in recent years and have a considerable impact on human well-being in terms of attributable deaths and disability-adjusted life years. Yet many mechanisms underlying bacterial pathogenesis are still poorly understood. Here, we introduce the BacFITBase database for the systematic characterization of bacterial proteins relevant for host infection aimed to enable the identification of new antibiotic targets. BacFITBase is manually curated and contains more than 90 000 entries with information on the contribution of individual genes to bacterial fitness under in vivo infection conditions in a range of host species. The data were collected from 15 different studies in which transposon mutagenesis was performed, including top-priority pathogens such as Acinetobacter baumannii and Campylobacter jejuni, for both of which increasing antibiotic resistance has been reported. Overall, BacFITBase includes information on 15 pathogenic bacteria and 5 host vertebrates across 10 different tissues. It is freely available at www.tartaglialab.com/bacfitbase.
BacFITBase: A database to assess the relevance of bacterial genes during host infection / Rendon, J. M.; Lang, B.; Tartaglia, G. G.; Burgas, M. T.. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - 48:1(2020), pp. D511-D516. [10.1093/nar/gkz931]
| Titolo: | BacFITBase: A database to assess the relevance of bacterial genes during host infection | |
| Autori: | ||
| Data di pubblicazione: | 2020 | |
| Rivista: | ||
| Citazione: | BacFITBase: A database to assess the relevance of bacterial genes during host infection / Rendon, J. M.; Lang, B.; Tartaglia, G. G.; Burgas, M. T.. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - 48:1(2020), pp. D511-D516. [10.1093/nar/gkz931] | |
| Handle: | http://hdl.handle.net/11573/1451087 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
File allegati a questo prodotto
| File | Note | Tipologia | Licenza | |
|---|---|---|---|---|
| Rendon_ BacFITBase_2020.pdf | Versione editoriale (versione pubblicata con il layout dell'editore) |  | Open Access Visualizza/Apri |
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