Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor comprising hereditary or sporadic form with frequent mutations in the rearranged during transfection (RET) or RAS genes. Diagnosis is based on presence of thyroid tumor mass with altered levels of calcitonin (Ctn) and carcinoembryonal antigen (CEA) in the serum and/or in the cytological smears from fine needle aspiration biopsies. Treatment consists of total thyroidectomy, followed by tyrosine kinase inhibitors (TKi) in case of disease persistence. During TKi treatment, Ctn and CEA levels can fluctuate regardless of tumor volume, metastasis or response to therapy. Research for more reliable non-invasive biomarkers in MTC is still underway. In this context, circulating nucleic acids, namely circulating microRNAs (miRNAs) and cell free DNA (cfDNA), have been evaluated by different research groups. Aiming to shed light on whether miRNAs and cfDNA are suitable as MTC biomarkers we searched three different databases, PubMed, Scopus, WOS and reviewed literature. We classified 83 publications fulfilling our search criteria and summarized the results. We report data on miRNA and cfDNA that can be evaluated for validation in independent studies and clinical application.

Role of tissue and circulating microRNA and DNA as biomarkers in medullary thyroid cancer / Chiacchiarini, Martina; Trocchianesi, Sofia; Besharat, Zein Mersini; Po, Agnese; Ferretti, Elisabetta. - In: PHARMACOLOGY & THERAPEUTICS. - ISSN 0163-7258. - (2020), p. 107708. [10.1016/j.pharmthera.2020.107708]

Role of tissue and circulating microRNA and DNA as biomarkers in medullary thyroid cancer

Chiacchiarini, Martina
Primo
;
Trocchianesi, Sofia;Besharat, Zein Mersini;Po, Agnese;Ferretti, Elisabetta
Ultimo
2020

Abstract

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor comprising hereditary or sporadic form with frequent mutations in the rearranged during transfection (RET) or RAS genes. Diagnosis is based on presence of thyroid tumor mass with altered levels of calcitonin (Ctn) and carcinoembryonal antigen (CEA) in the serum and/or in the cytological smears from fine needle aspiration biopsies. Treatment consists of total thyroidectomy, followed by tyrosine kinase inhibitors (TKi) in case of disease persistence. During TKi treatment, Ctn and CEA levels can fluctuate regardless of tumor volume, metastasis or response to therapy. Research for more reliable non-invasive biomarkers in MTC is still underway. In this context, circulating nucleic acids, namely circulating microRNAs (miRNAs) and cell free DNA (cfDNA), have been evaluated by different research groups. Aiming to shed light on whether miRNAs and cfDNA are suitable as MTC biomarkers we searched three different databases, PubMed, Scopus, WOS and reviewed literature. We classified 83 publications fulfilling our search criteria and summarized the results. We report data on miRNA and cfDNA that can be evaluated for validation in independent studies and clinical application.
2020
Biomarkers; Disease staging; Medullary thyroid cancer; Medullary thyroid carcinoma; Medullary thyroid neoplasm; Therapeutic response; cfDNA; microRNA
01 Pubblicazione su rivista::01a Articolo in rivista
Role of tissue and circulating microRNA and DNA as biomarkers in medullary thyroid cancer / Chiacchiarini, Martina; Trocchianesi, Sofia; Besharat, Zein Mersini; Po, Agnese; Ferretti, Elisabetta. - In: PHARMACOLOGY & THERAPEUTICS. - ISSN 0163-7258. - (2020), p. 107708. [10.1016/j.pharmthera.2020.107708]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1449521
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