Numerous evidence has demonstrated the involvement in growth control of interferon (IFN) regulatory factor-1 (IRF-1), which shows tumor suppressor activity. IRF-1 is a well-studied member of the IRF transcription factors that reveals functional diversity in the regulation of cellular response by activating expression of a diverse set of target genes, depending on the cell type and on the specific stimuli. IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types. Furthermore, different aspects of the tumor suppressor function of IRF-1 may be explained, at least in part, by the observations that IRF-1 is a regulator of cell cycle and apoptosis and that its inactivation accelerates cell transformation. Studies on gene knockout mice contributed greatly to the clarification of these multiple IRF-1 functions. We summarize our current knowledge of the antigrowth effect of IRF-1, focusing also on a more general involvement of IRF-1 in mediating negative regulation of cell growth induced by numerous cytokines and other biologic response modifiers.

IRF-1 as a negative regulator of cell proliferation / Romeo, Giovanna; G., Fiorucci; M. V., Chiantore; Z. A., Percario; S., Vannucchi; E., Affabris. - In: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. - ISSN 1079-9907. - STAMPA. - 22:1(2002), pp. 39-47. [10.1089/107999002753452647]

IRF-1 as a negative regulator of cell proliferation

ROMEO, Giovanna;
2002

Abstract

Numerous evidence has demonstrated the involvement in growth control of interferon (IFN) regulatory factor-1 (IRF-1), which shows tumor suppressor activity. IRF-1 is a well-studied member of the IRF transcription factors that reveals functional diversity in the regulation of cellular response by activating expression of a diverse set of target genes, depending on the cell type and on the specific stimuli. IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types. Furthermore, different aspects of the tumor suppressor function of IRF-1 may be explained, at least in part, by the observations that IRF-1 is a regulator of cell cycle and apoptosis and that its inactivation accelerates cell transformation. Studies on gene knockout mice contributed greatly to the clarification of these multiple IRF-1 functions. We summarize our current knowledge of the antigrowth effect of IRF-1, focusing also on a more general involvement of IRF-1 in mediating negative regulation of cell growth induced by numerous cytokines and other biologic response modifiers.
2002
01 Pubblicazione su rivista::01a Articolo in rivista
IRF-1 as a negative regulator of cell proliferation / Romeo, Giovanna; G., Fiorucci; M. V., Chiantore; Z. A., Percario; S., Vannucchi; E., Affabris. - In: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. - ISSN 1079-9907. - STAMPA. - 22:1(2002), pp. 39-47. [10.1089/107999002753452647]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/144940
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