The goal of supporting and directing tissue regeneration requires the design of new, advanced materials, with features like biocompatibility, biodegradability and adequate mechanical properties. Our work was focused on developing a new injectable biomimetic composite material, based on a peptidic hydrogel and calcium phosphates with the aim of mimicking the chemical composition of natural bone tissue. Arg-Gly-Asp-grafted chitosan was used to promote cell adhesion. The obtained composite hydrogel was characterized with differential scanning calorimetry (DSC) measurements, rheological analysis, field emission scanning electron microscopy (FE-SEM), Fourier Transform Infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) measurements. The biological responsiveness was assessed using the MG-63 human osteoblast cell line.

Biosynthesis of innovative calcium phosphate/hydrogel composites. Physicochemical and biological characterisation / Chronopoulou, Laura; Cacciotti, Ilaria; Amalfitano, Adriana; DI NITTO, Antonio; D'Arienzo, Veronica; Nocca, Giuseppina; Palocci, Cleofe. - In: NANOTECHNOLOGY. - ISSN 1361-6528. - (2020). [10.1088/1361-6528/abc5f6]

Biosynthesis of innovative calcium phosphate/hydrogel composites. Physicochemical and biological characterisation

Laura Chronopoulou
Primo
;
Adriana Amalfitano;Antonio Di Nitto;Veronica D’Arienzo;Cleofe Palocci
2020

Abstract

The goal of supporting and directing tissue regeneration requires the design of new, advanced materials, with features like biocompatibility, biodegradability and adequate mechanical properties. Our work was focused on developing a new injectable biomimetic composite material, based on a peptidic hydrogel and calcium phosphates with the aim of mimicking the chemical composition of natural bone tissue. Arg-Gly-Asp-grafted chitosan was used to promote cell adhesion. The obtained composite hydrogel was characterized with differential scanning calorimetry (DSC) measurements, rheological analysis, field emission scanning electron microscopy (FE-SEM), Fourier Transform Infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) measurements. The biological responsiveness was assessed using the MG-63 human osteoblast cell line.
2020
hydrogel; composite; cell adhesion
01 Pubblicazione su rivista::01a Articolo in rivista
Biosynthesis of innovative calcium phosphate/hydrogel composites. Physicochemical and biological characterisation / Chronopoulou, Laura; Cacciotti, Ilaria; Amalfitano, Adriana; DI NITTO, Antonio; D'Arienzo, Veronica; Nocca, Giuseppina; Palocci, Cleofe. - In: NANOTECHNOLOGY. - ISSN 1361-6528. - (2020). [10.1088/1361-6528/abc5f6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1449080
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