The delivery of therapeutic proteins is one of the greatest challenges in the treatment of human diseases. In this frame, ferritins occupy a very special place. Thanks to their hollow spherical structure, they are used as modular nanocages for the delivery of anticancer drugs. More recently, the possibility of encapsulating even small proteins with enzymatic or cytotoxic activity is emerging. Among all ferritins, particular interest is paid to the Archaeoglobus fulgidus one, due to its peculiar ability to associate/dissociate in physiological conditions. This protein has also been engineered to allow recognition of human receptors and used in vitro for the delivery of cytotoxic proteins with extremely promising results.

Ferritin nanocages for protein delivery to tumor cells / Palombarini, F.; Di Fabio, E.; Boffi, A.; Macone, A.; Bonamore, A.. - In: MOLECULES. - ISSN 1420-3049. - 25:4(2020), p. 825. [10.3390/molecules25040825]

Ferritin nanocages for protein delivery to tumor cells

Palombarini F.;Di Fabio E.;Boffi A.;Macone A.
;
Bonamore A.
2020

Abstract

The delivery of therapeutic proteins is one of the greatest challenges in the treatment of human diseases. In this frame, ferritins occupy a very special place. Thanks to their hollow spherical structure, they are used as modular nanocages for the delivery of anticancer drugs. More recently, the possibility of encapsulating even small proteins with enzymatic or cytotoxic activity is emerging. Among all ferritins, particular interest is paid to the Archaeoglobus fulgidus one, due to its peculiar ability to associate/dissociate in physiological conditions. This protein has also been engineered to allow recognition of human receptors and used in vitro for the delivery of cytotoxic proteins with extremely promising results.
2020
archaeoglobus fulgidus; drug delivery; ferritin; nanocarrier; TfR1 receptor; therapeutic proteins; tumor cells
01 Pubblicazione su rivista::01a Articolo in rivista
Ferritin nanocages for protein delivery to tumor cells / Palombarini, F.; Di Fabio, E.; Boffi, A.; Macone, A.; Bonamore, A.. - In: MOLECULES. - ISSN 1420-3049. - 25:4(2020), p. 825. [10.3390/molecules25040825]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1448470
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