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EnglishPotential celiac disease (PCD) is defined by the presence of positive serum antibodies, HLA-DQ2/DQ8 haplotypes, and a normal small intestinal mucosa (Marsh grade 0-1). This condition occurs in one-fifth of celiac disease (CD) patients and usually represents a clinical challenge. We reviewed genetic, histologic, and clinical features of this specific condition by performing a systematic search on MEDLINE, Embase, and Scholar database. Accordingly, we identified different genetic features in patients with PCD compared to the classical forms. Frequently, signs of inflammation (deposits of immunoglobulin A (IgA) and/or increased number of intraepithelial lymphocytes) can be clearly identify in the mucosa of PCD patients after an accurate histological assessment. Finally, the main challenge is represented by the treatment: the gluten-free diet should be considered only in the presence of gluten-dependent symptoms in both children and adults. What is known: (i) potential celiac disease (PCD) occurs in one-fifth of all celiac diseases (CD), and (ii) despite the absence of classical lesions, clear signs of inflammation are often detectable. What is new: (i) patients with PCD show different genetic features, and (ii) the presence of gluten-dependent symptoms is the main determinant to initiate the gluten-free diet, after a complete diagnostic work-up.
The challenge of treatment in potential celiac disease / Trovato, C. M.; Montuori, M.; Valitutti, F.; Leter, B.; Cucchiara, S.; Oliva, S.. - In: GASTROENTEROLOGY RESEARCH AND PRACTICE. - ISSN 1687-6121. - 2019(2019).
| Titolo: | The challenge of treatment in potential celiac disease | |
| Autori: | CUCCHIARA, Salvatore (Penultimo) OLIVA, SALVATORE (Ultimo) | |
| Data di pubblicazione: | 2019 | |
| Rivista: | ||
| Citazione: | The challenge of treatment in potential celiac disease / Trovato, C. M.; Montuori, M.; Valitutti, F.; Leter, B.; Cucchiara, S.; Oliva, S.. - In: GASTROENTEROLOGY RESEARCH AND PRACTICE. - ISSN 1687-6121. - 2019(2019). | |
| Handle: | http://hdl.handle.net/11573/1448381 | |
| Appartiene alla tipologia: | 01g Articolo di rassegna (Review) |
File allegati a questo prodotto
| File | Note | Tipologia | Licenza | |
|---|---|---|---|---|
| Trovato_Celiac-disease_2019.pdf | Versione editoriale (versione pubblicata con il layout dell'editore) |  | Open Access Visualizza/Apri |
http://hdl.handle.net/11573/1448381
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