NK cells vigorously proliferate during viral infections. During the course of murine CMV infection, this response becomes dominated by the preferential proliferation of NK cells that express the activation receptor Ly49H. The factors driving such selective NK cell proliferation have not been characterized. In this study, we demonstrate that preferential NK cell proliferation is dependent on DAP12-mediated signaling following the binding of Ly49H to its virally encoded ligand, m157. Ly49H signaling through DAP12 appears to directly augment NK cell sensitivity to low concentrations of proproliferative cytokines such as IL-15. The impact of Ly49H-mediated signaling on NK cell proliferation is masked in the presence of high concentrations of proproliferative cytokines that nonselectively drive all NK cells to proliferate.

DAP12 signaling directly augments pro-proliferative cytokine stimulation of NK cells during viral infections / A. R., French; H., Sjolin; S., Kim; R., Koka; L., Yang; D. A., Young; Cerboni, Cristina; E., Tomasello; A., Ma; E., Vivier; K., Karre; W. M., Yokoyama. - In: JOURNAL OF IMMUNOLOGY. - ISSN 0022-1767. - 177 (8):(2006), pp. 4981-4990.

DAP12 signaling directly augments pro-proliferative cytokine stimulation of NK cells during viral infections.

CERBONI, CRISTINA;
2006

Abstract

NK cells vigorously proliferate during viral infections. During the course of murine CMV infection, this response becomes dominated by the preferential proliferation of NK cells that express the activation receptor Ly49H. The factors driving such selective NK cell proliferation have not been characterized. In this study, we demonstrate that preferential NK cell proliferation is dependent on DAP12-mediated signaling following the binding of Ly49H to its virally encoded ligand, m157. Ly49H signaling through DAP12 appears to directly augment NK cell sensitivity to low concentrations of proproliferative cytokines such as IL-15. The impact of Ly49H-mediated signaling on NK cell proliferation is masked in the presence of high concentrations of proproliferative cytokines that nonselectively drive all NK cells to proliferate.
2006
01 Pubblicazione su rivista::01a Articolo in rivista
DAP12 signaling directly augments pro-proliferative cytokine stimulation of NK cells during viral infections / A. R., French; H., Sjolin; S., Kim; R., Koka; L., Yang; D. A., Young; Cerboni, Cristina; E., Tomasello; A., Ma; E., Vivier; K., Karre; W. M., Yokoyama. - In: JOURNAL OF IMMUNOLOGY. - ISSN 0022-1767. - 177 (8):(2006), pp. 4981-4990.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/144762
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