The oral cavity, an essential part of the upper aerodigestive tract, is believed to play an important role in the pathogenicity and transmission of SARS-CoV-2. The identification of targeted antiviral mouth rinses to reduce salivary viral load would contribute to reducing the COVID-19 pandemic. While awaiting the results of significant clinical studies, which to date do not exist, the commercial availability of mouth rinses leads us to search among them for reagents that would have specific antiviral properties with respect to SARS-CoV-2. The challenges facing this target were examined for 7 reagents found in commercially available mouth rinses and listed on the ClinicalTrials.gov website: povidone-iodine, chlorhexidine, hydrogen peroxide, cyclodextrin, Citrox, cetylpyridinium chloride, and essential oils. Because SARS-CoV-2 is an enveloped virus, many reagents target the outer lipid membrane. Moreover, some of them can act on the capsid by denaturing proteins. Until now, there has been no scientific evidence to recommend mouth rinses with an anti-SARS-CoV-2 effect to control the viral load in the oral cavity. This critical review indicates that current knowledge of these reagents would likely improve trends in salivary viral load status. This finding is a strong sign to encourage clinical research for which quality protocols are already available in the literature.

Antiviral activity of reagents in mouth rinses against SARS-CoV-2 / Carrouel, F; Gonçalves, L S; Conte, M P; Campus, G; Fisher, J; Fraticelli, L; Gadea-Deschamps, E; Ottolenghi, L; Bourgeois, D. - In: JOURNAL OF DENTAL RESEARCH. - ISSN 0022-0345. - 100:2(2021), pp. 124-132. [10.1177/0022034520967933]

Antiviral activity of reagents in mouth rinses against SARS-CoV-2

Conte, M P;Ottolenghi, L
Penultimo
;
2021

Abstract

The oral cavity, an essential part of the upper aerodigestive tract, is believed to play an important role in the pathogenicity and transmission of SARS-CoV-2. The identification of targeted antiviral mouth rinses to reduce salivary viral load would contribute to reducing the COVID-19 pandemic. While awaiting the results of significant clinical studies, which to date do not exist, the commercial availability of mouth rinses leads us to search among them for reagents that would have specific antiviral properties with respect to SARS-CoV-2. The challenges facing this target were examined for 7 reagents found in commercially available mouth rinses and listed on the ClinicalTrials.gov website: povidone-iodine, chlorhexidine, hydrogen peroxide, cyclodextrin, Citrox, cetylpyridinium chloride, and essential oils. Because SARS-CoV-2 is an enveloped virus, many reagents target the outer lipid membrane. Moreover, some of them can act on the capsid by denaturing proteins. Until now, there has been no scientific evidence to recommend mouth rinses with an anti-SARS-CoV-2 effect to control the viral load in the oral cavity. This critical review indicates that current knowledge of these reagents would likely improve trends in salivary viral load status. This finding is a strong sign to encourage clinical research for which quality protocols are already available in the literature.
2021
COVID-19; clinical trial; mouthwashes; oral; saliva; viral load
01 Pubblicazione su rivista::01a Articolo in rivista
Antiviral activity of reagents in mouth rinses against SARS-CoV-2 / Carrouel, F; Gonçalves, L S; Conte, M P; Campus, G; Fisher, J; Fraticelli, L; Gadea-Deschamps, E; Ottolenghi, L; Bourgeois, D. - In: JOURNAL OF DENTAL RESEARCH. - ISSN 0022-0345. - 100:2(2021), pp. 124-132. [10.1177/0022034520967933]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1447016
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