Introduction: To better understand the pathophysiology of isolated head tremor, we investigated somatosensory temporal discrimination threshold (STDT) and dopaminergic neurotransmission with 123I-FP-CIT (DAT-SPECT) in patients with isolated head tremor, as well as potential correlations with their clinical features. Methods: We enrolled 14 patients with isolated head tremor who underwent clinical examination, STDT testing, and DAT-SPECT. Results: We found normal radiotracer uptake in both striata as assessed with DAT-SPECT examination, but higher STDT values in patients as compared to healthy subjects. No significant correlations emerged between STDT values, specific binding ratios of radiotracer uptake, and demographic or clinical features. Conclusion: Our study found normal radiotracer uptake with DAT-SPECT examination, suggesting dopaminergic neurotransmission integrity in patients with isolated head tremor. Patients with isolated head tremor exhibited an abnormally elevated STDT. Both results support the hypothesis that isolated head tremor should be considered a form of dystonia.

Isolated head tremor: a DAT-SPECT and somatosensory temporal discrimination study / Ferrazzano, G.; Frantellizzi, V.; De Bartolo, M. I.; De Feo, M. S.; Conte, A.; Fabbrini, G.; De Vincentis, G.; Berardelli, A.. - In: PARKINSONISM & RELATED DISORDERS. - ISSN 1353-8020. - 81:(2020), pp. 56-59. [10.1016/j.parkreldis.2020.10.015]

Isolated head tremor: a DAT-SPECT and somatosensory temporal discrimination study

Ferrazzano G.
Primo
;
Frantellizzi V.
Secondo
;
De Bartolo M. I.;De Feo M. S.;Conte A.;Fabbrini G.;De Vincentis G.
Penultimo
;
Berardelli A.
Ultimo
2020

Abstract

Introduction: To better understand the pathophysiology of isolated head tremor, we investigated somatosensory temporal discrimination threshold (STDT) and dopaminergic neurotransmission with 123I-FP-CIT (DAT-SPECT) in patients with isolated head tremor, as well as potential correlations with their clinical features. Methods: We enrolled 14 patients with isolated head tremor who underwent clinical examination, STDT testing, and DAT-SPECT. Results: We found normal radiotracer uptake in both striata as assessed with DAT-SPECT examination, but higher STDT values in patients as compared to healthy subjects. No significant correlations emerged between STDT values, specific binding ratios of radiotracer uptake, and demographic or clinical features. Conclusion: Our study found normal radiotracer uptake with DAT-SPECT examination, suggesting dopaminergic neurotransmission integrity in patients with isolated head tremor. Patients with isolated head tremor exhibited an abnormally elevated STDT. Both results support the hypothesis that isolated head tremor should be considered a form of dystonia.
2020
DAT-SPECT; dystonia; isolated head tremor; somatosensory temporal discrimination
01 Pubblicazione su rivista::01a Articolo in rivista
Isolated head tremor: a DAT-SPECT and somatosensory temporal discrimination study / Ferrazzano, G.; Frantellizzi, V.; De Bartolo, M. I.; De Feo, M. S.; Conte, A.; Fabbrini, G.; De Vincentis, G.; Berardelli, A.. - In: PARKINSONISM & RELATED DISORDERS. - ISSN 1353-8020. - 81:(2020), pp. 56-59. [10.1016/j.parkreldis.2020.10.015]
File allegati a questo prodotto
File Dimensione Formato  
Ferrazzano_Isolated_2020.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 356.6 kB
Formato Adobe PDF
356.6 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1446037
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 6
social impact