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EnglishConflicting evidence regarding the use of hydroxychloroquine (HCQ) and azithromycin for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection do exist. We performed a retrospective single-center cohort study including 377 consecutive patients admitted for pneumonia related to coronavirus disease 2019 (COVID-19). Of these, 297 were in combination treatment, 17 were on HCQ alone, and 63 did not receive either of these 2 drugs because of contraindications. The primary end point was in-hospital death. Mean age was 71.8 ± 13.4 years and 34.2% were women. We recorded 146 deaths: 35 in no treatment, 7 in HCQ treatment group, and 102 in HCQ + azithromycin treatment group (log rank test for Kaplan–Meier curve P < 0.001). At multivariable Cox proportional hazard regression analysis, age (hazard ratio (HR) 1.057, 95% confidence interval (CI) 1.035–1.079, P < 0.001), mechanical ventilation/continuous positive airway pressure (HR 2.726, 95% CI 1.823–4.074, P < 0.001), and C reactive protein above the median (HR 2.191, 95% CI 1.479–3.246, P < 0.001) were directly associated with death, whereas use of HCQ + azithromycin (vs. no treatment; HR 0.265, 95% CI 0.171–0.412, P < 0.001) was inversely associated. In this study, we found a reduced in-hospital mortality in patients treated with a combination of HCQ and azithromycin after adjustment for comorbidities. A large randomized trial is necessary to confirm these findings.
Effect of combination therapy of hydroxychloroquine and azithromycin on mortality in patients with COVID-19 / Lauriola, M.; Pani, A.; Ippoliti, G.; Mortara, A.; Milighetti, S.; Mazen, M.; Perseghin, G.; Pastori, D.; Grosso, P.; Scaglione, F.. - In: CLINICAL AND TRANSLATIONAL SCIENCE. - ISSN 1752-8054. - 13:6(2020), pp. 1071-1076.
| Titolo: | Effect of combination therapy of hydroxychloroquine and azithromycin on mortality in patients with COVID-19 | |
| Autori: | ||
| Data di pubblicazione: | 2020 | |
| Rivista: | ||
| Citazione: | Effect of combination therapy of hydroxychloroquine and azithromycin on mortality in patients with COVID-19 / Lauriola, M.; Pani, A.; Ippoliti, G.; Mortara, A.; Milighetti, S.; Mazen, M.; Perseghin, G.; Pastori, D.; Grosso, P.; Scaglione, F.. - In: CLINICAL AND TRANSLATIONAL SCIENCE. - ISSN 1752-8054. - 13:6(2020), pp. 1071-1076. | |
| Handle: | http://hdl.handle.net/11573/1444797 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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| Lauriola_Effect-of-Combination_2020.pdf | Versione editoriale (versione pubblicata con il layout dell'editore) |  | Open Access Visualizza/Apri |
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