We describe three critically ill patients who received drugs with K(ATP) channel-opening properties and subsequently developed severe life-threatening complications, including hyperkalaemia and cardiovascular disturbances. Administration of the sulfonylurea-receptor inhibitor glibenclamide promptly reversed these abnormalities. Over the past 3 years, we have seen this syndrome and response in five patients taking nicorandil, ciclosporin, or isoflurane, which suggests that this disorder arises more frequently than is currently realised.

Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide / Mervyn, Singer; Coluzzi, Flaminia; A., Obrien; Lucie H., Clapp. - In: THE LANCET. - ISSN 0140-6736. - 365:9474(2005), pp. 1873-1875. [10.1016/s0140-6736(05)66619-6]

Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide

COLUZZI, FLAMINIA;
2005

Abstract

We describe three critically ill patients who received drugs with K(ATP) channel-opening properties and subsequently developed severe life-threatening complications, including hyperkalaemia and cardiovascular disturbances. Administration of the sulfonylurea-receptor inhibitor glibenclamide promptly reversed these abnormalities. Over the past 3 years, we have seen this syndrome and response in five patients taking nicorandil, ciclosporin, or isoflurane, which suggests that this disorder arises more frequently than is currently realised.
2005
01 Pubblicazione su rivista::01a Articolo in rivista
Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide / Mervyn, Singer; Coluzzi, Flaminia; A., Obrien; Lucie H., Clapp. - In: THE LANCET. - ISSN 0140-6736. - 365:9474(2005), pp. 1873-1875. [10.1016/s0140-6736(05)66619-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/144417
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