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EnglishObjective: The main limitation of neuromodulation techniques is inter-subject variability. Combining theta-burst stimulation (TBS) with gamma-transcranial alternating current stimulation (γ-tACS) allows to shape cortical plasticity. However, it is unknown whether γ-tACS modifies TBS-induced response variability. In this study, we measured the inter-subject variability of TBS-γ tACS and controlled the effect of the Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism. Methods: Intermittent TBS (iTBS)-sham tACS, iTBS-γ tACS, continuous TBS (cTBS)-sham tACS, and cTBS-γ tACS were applied in randomised sessions. Inter-subject variability was measured using grand average and clustering methods. TBS-γ tACS effects on motor evoked potentials (MEP) were compared between Val/Val and Met carriers. Results: We found that γ-tACS boosted iTBS-induced MEP facilitation and cancelled cTBS-induced MEP depression. Grand average analysis showed that γ-tACS prominently increased the percentage of iTBS responders and cTBS non-responders. The clustering method demonstrated that TBS-γ tACS response varied between subjects, a phenomenon unrelated to the BDNF genotype. Conclusions: Enhancing γ oscillations through tACS boosts iTBS-induced LTP-like plasticity and suppresses cTBS-induced LTD-like plasticity of the primary motor cortex in a reliable manner. The BDNF Val66Met polymorphism does not influence these effects. Significance: Since γ-tACS significantly increases the number of iTBS responders, it may be used in clinical settings.
Gamma-transcranial alternating current stimulation and theta-burst stimulation. inter-subject variability and the role of BDNF / Guerra, A.; Asci, F.; Zampogna, A.; D'Onofrio, V.; Petrucci, S.; Ginevrino, M.; Berardelli, A.; Suppa, A.. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 131:11(2020), pp. 2691-2699. [10.1016/j.clinph.2020.08.017]
| Titolo: | Gamma-transcranial alternating current stimulation and theta-burst stimulation. inter-subject variability and the role of BDNF | |
| Autori: | ||
| Data di pubblicazione: | 2020 | |
| Rivista: | ||
| Citazione: | Gamma-transcranial alternating current stimulation and theta-burst stimulation. inter-subject variability and the role of BDNF / Guerra, A.; Asci, F.; Zampogna, A.; D'Onofrio, V.; Petrucci, S.; Ginevrino, M.; Berardelli, A.; Suppa, A.. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 131:11(2020), pp. 2691-2699. [10.1016/j.clinph.2020.08.017] | |
| Handle: | http://hdl.handle.net/11573/1442557 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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