Angiotensin II (Ang II) exerts its effects by acting on two receptors: the angiotensin type 1 receptor (AT1R) and the angiotensin type 2 receptor (AT2R). Whereas AT1R seems to mediate most of the recognised actions of Ang II, it appears that AT2R opposes, in part, the actions mediated by AT1R. AT2R may have the homeostatic role of exerting a countervailing influence on excess stimulation of AT1R. Since AT2R is expressed in adult tissues in smaller numbers than AT1R, the actions and cell signalling of AT2R have been less well characterised than those of AT1R. In vitro and in vivo studies show that AT2R mediates vasodilation, antigrowth and proapoptotic effects. AT2R also modulates the progression of atherosclerosis. A protective role of AT2R in the cardiovascular system has been confirmed in humans, mainly during chronic AT1R inhibition, which may contribute in part to the mechanism of action of angiotensin receptor blockers. © 2007 Adis Data Information BV. All rights reserved.
AT2 Receptors in the Cardiovascualar System / Savoia, Carmine; Schiffrin, El. - In: HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION. - ISSN 1120-9879. - 14 (2):(2007), pp. 63-68. [10.2165/00151642-200714020-00002]
AT2 Receptors in the Cardiovascualar System.
SAVOIA, Carmine;
2007
Abstract
Angiotensin II (Ang II) exerts its effects by acting on two receptors: the angiotensin type 1 receptor (AT1R) and the angiotensin type 2 receptor (AT2R). Whereas AT1R seems to mediate most of the recognised actions of Ang II, it appears that AT2R opposes, in part, the actions mediated by AT1R. AT2R may have the homeostatic role of exerting a countervailing influence on excess stimulation of AT1R. Since AT2R is expressed in adult tissues in smaller numbers than AT1R, the actions and cell signalling of AT2R have been less well characterised than those of AT1R. In vitro and in vivo studies show that AT2R mediates vasodilation, antigrowth and proapoptotic effects. AT2R also modulates the progression of atherosclerosis. A protective role of AT2R in the cardiovascular system has been confirmed in humans, mainly during chronic AT1R inhibition, which may contribute in part to the mechanism of action of angiotensin receptor blockers. © 2007 Adis Data Information BV. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
