The nuclear envelope compartmentalizes chromatin in eukaryotic cells. The main nuclear envelope components are lamins that associate with a panoply of factors, including the LEM domain proteins. The nuclear envelope of mammalian cells opens up during cell division. It is reassembled and associated with chromatin at the end of mitosis when telomeres tether to the nuclear periphery. Lamins, LEM domain proteins, and DNA binding factors, as BAF, contribute to the reorganization of chromatin. In this context, an emerging role is that of the ESCRT complex, a machinery operating in multiple membrane assembly pathways, including nuclear envelope reformation. Research in this area is unraveling how, mechanistically, ESCRTs link to nuclear envelope associated factors as LEM domain proteins. Importantly, ESCRTs work also during interphase for repairing nuclear envelope ruptures. Altogether the advances in this field are giving new clues for the interpretation of diseases implicating nuclear envelope fragility, as laminopathies and cancer.

Interplay of the nuclear envelope with chromatin in physiology and pathology / Burla, R; La Torre, M; Maccaroni, K; Vernì, Fiammetta; Giunta, S; Saggio, I.. - In: NUCLEUS. - ISSN 1949-1034. - 11:1(2020), pp. 205-218. [10.1080/19491034.2020.1806661]

Interplay of the nuclear envelope with chromatin in physiology and pathology

Burla R;La Torre M;Maccaroni K;Vernì Fiammetta;Giunta S;Saggio I.
2020

Abstract

The nuclear envelope compartmentalizes chromatin in eukaryotic cells. The main nuclear envelope components are lamins that associate with a panoply of factors, including the LEM domain proteins. The nuclear envelope of mammalian cells opens up during cell division. It is reassembled and associated with chromatin at the end of mitosis when telomeres tether to the nuclear periphery. Lamins, LEM domain proteins, and DNA binding factors, as BAF, contribute to the reorganization of chromatin. In this context, an emerging role is that of the ESCRT complex, a machinery operating in multiple membrane assembly pathways, including nuclear envelope reformation. Research in this area is unraveling how, mechanistically, ESCRTs link to nuclear envelope associated factors as LEM domain proteins. Importantly, ESCRTs work also during interphase for repairing nuclear envelope ruptures. Altogether the advances in this field are giving new clues for the interpretation of diseases implicating nuclear envelope fragility, as laminopathies and cancer.
2020
Chromatin; midbody; ESCRT; telomeres; nuclear envelope; cancer; genome rearrangements
01 Pubblicazione su rivista::01a Articolo in rivista
Interplay of the nuclear envelope with chromatin in physiology and pathology / Burla, R; La Torre, M; Maccaroni, K; Vernì, Fiammetta; Giunta, S; Saggio, I.. - In: NUCLEUS. - ISSN 1949-1034. - 11:1(2020), pp. 205-218. [10.1080/19491034.2020.1806661]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1441392
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