High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-specific, and enriched in genes for neuronal proteins and synaptic factors. These features suggested that circRNAs are key components of an important layer of neuronal gene expression regulation, with known and anticipated functions. Here, we review major recognized aspects of circRNA biogenesis, metabolism and biological activities, examining potential new functions in the context of the nervous system.

The Secret Garden of Neuronal circRNAs / Gasparini, S.; Licursi, V.; Presutti, C.; Mannironi, C.. - In: CELLS. - ISSN 2073-4409. - 9:8(2020). [10.3390/cells9081815]

The Secret Garden of Neuronal circRNAs

Gasparini S.;Licursi V.;Presutti C.
;
2020

Abstract

High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-specific, and enriched in genes for neuronal proteins and synaptic factors. These features suggested that circRNAs are key components of an important layer of neuronal gene expression regulation, with known and anticipated functions. Here, we review major recognized aspects of circRNA biogenesis, metabolism and biological activities, examining potential new functions in the context of the nervous system.
2020
circRNA; ncRNA; miRNA; gene regulation; nervous system
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The Secret Garden of Neuronal circRNAs / Gasparini, S.; Licursi, V.; Presutti, C.; Mannironi, C.. - In: CELLS. - ISSN 2073-4409. - 9:8(2020). [10.3390/cells9081815]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1438971
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