Recent advancement in the area of asymmetric organocatalysis led to the development of new methodologies for the construction of valuable enantiopure molecules, including various heterocycles. As one of the latter class of compounds tetrahydropyrans (THPs) constitute a core structure of a wide array of bioactive natural products. A noticeable growth has been observed in the asymmetric synthesis of THPs using small organic molecules as catalysts. This Tutorial Review describes the organocatalytic methods available to furnish THPs as well as the application of these methodologies in the total synthesis of THP-based natural products. © 2017 The Royal Society of Chemistry.

Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis / Vetica, Fabrizio; Chauhan, Pankaj; Dochain, Simon; Enders, Dieter. - In: CHEMICAL SOCIETY REVIEWS. - ISSN 0306-0012. - 46:6(2017), pp. 1661-1674. [10.1039/c6cs00757k]

Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis

Vetica, Fabrizio;
2017

Abstract

Recent advancement in the area of asymmetric organocatalysis led to the development of new methodologies for the construction of valuable enantiopure molecules, including various heterocycles. As one of the latter class of compounds tetrahydropyrans (THPs) constitute a core structure of a wide array of bioactive natural products. A noticeable growth has been observed in the asymmetric synthesis of THPs using small organic molecules as catalysts. This Tutorial Review describes the organocatalytic methods available to furnish THPs as well as the application of these methodologies in the total synthesis of THP-based natural products. © 2017 The Royal Society of Chemistry.
2017
organocatalysts; Squaramide; 3-hydroxybutanal
01 Pubblicazione su rivista::01a Articolo in rivista
Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis / Vetica, Fabrizio; Chauhan, Pankaj; Dochain, Simon; Enders, Dieter. - In: CHEMICAL SOCIETY REVIEWS. - ISSN 0306-0012. - 46:6(2017), pp. 1661-1674. [10.1039/c6cs00757k]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1438012
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